Journal Article

DKFZ-2025-01437

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing.

Rausch, T. ; Schäfer, H. ; Bein, J. ; Mölder, F. ; Beeck, L. K. ; Kölsch, B. ; Borchert, S. ; Benes, V. ; Halbsguth, T. ; Brunnberg, U. ; Oellerich, T.DKFZ* ; Tousseyn, T. ; Ponzoni, M. ; Köster, J. ; Hansmann, M.-L. ; Küppers, R.DKFZ* ; Hartmann, S.

2025
Springer Nature London

Abstract: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare malignant lymphoma characterised by a few large tumour cells expressing B-cell antigens in an inflammatory background. T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is now considered to be closely related to NLPHL. Little is known about the mutational spectrum of the lymphoma cells in primary NLPHL and THRLBCL due to the rarity of the diseases and the technical challenges of analysing these tumours. Therefore, the aim of the present study was to elucidate mechanisms contributing to the pathogenesis of NLPHL and THRLBCL by whole genome sequencing of laser microdissected tumour cells from seven cases. We observed a heterogeneity of transforming events, with cases showing abundant somatic mutations, others with a predominance of structural variations, and cases with few aberrations. The genes that were most frequently affected by aberrations encode factors influencing JAK-STAT, NF-κB, and/or WNT signaling, and apoptosis regulators. However, the mutated genes, such as SOCS3, JUNB, IRF1 and ITPKB, were not the typical targets known from classical Hodgkin lymphoma (cHL). Two cases showed recurrent rearrangements of BCL6 and CD74. In conclusion, our data enrich our understanding of NLPHL and THRLBCL and highlight common and distinct features with respect to cHL.

Note: 2025 Sep;39(9):2215-2225

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Frankfurt (FM01)
2. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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