%0 Journal Article
%A Muchadeyi, Muchandifunga
%A Hao, Shuang
%A Hernandez Villafuerte, Karla Vanessa
%A Khan, Shah Alam
%A Becker, Nikolaus
%A Krilaviciute, Agne
%A Seibold, Petra
%A Gulati, Roman
%A Albers, Peter
%A Schlander, Michael
%A Clements, Mark
%T Cost effectiveness analysis of prostate cancer screening strategies in Germany: A microsimulation study.
%J Radiation oncology investigations
%V 157
%N 8
%@ 1065-7541
%C New York, NY
%I Wiley Interscience
%M DKFZ-2025-01469
%P 1662-1679
%D 2025
%Z #EA:C100# / 2025 Oct 15;157(8):1662-1679
%X Prostate cancer (PCa) represents a significant public health challenge in Germany, with increasing incidence and economic impact. This study assessed the cost-effectiveness of 10 screening strategies: prostate-specific antigen-based risk-adaptive screening (PSA-RAS), with or without magnetic resonance imaging (MRI), in men starting at age 45 or 50 and stopping at 60 or 70, digital rectal examination (DRE) for ages 45-75 years, and no screening. Using a well calibrated microsimulation model (Swedish Prostata) from a statutory health insurance perspective, lifetime outcomes were evaluated, including cancer incidence, mortality, overdiagnosis, biopsies, life-years, and quality-adjusted life-years (QALYs) discounted annually at 3
%K QALYs (Other)
%K cost‐effectiveness analysis (Other)
%K magnetic resonance imaging (Other)
%K organised screening (Other)
%K prostate cancer (Other)
%K prostate‐specific antigen (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40665795
%R 10.1002/ijc.35513
%U https://inrepo02.dkfz.de/record/303022