Journal Article

DKFZ-2025-01479

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cell-specific analysis of microglia following partial brain proton irradiation in mice.

Nexhipi, S.DKFZ* ; Suckert, T.DKFZ* ; Soltwedel, J. ; Beyreuther, E. ; Noßol, M. ; Pecht, L. ; Boucsein, M.DKFZ* ; Schneider, M. ; Horst, F. ; Löck, S.DKFZ* ; Krause, M.DKFZ* ; Lühr, A.DKFZ* ; Dietrich, A.DKFZ*

2025
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.ctro.2025.101003

Abstract: • Inflammatory response is evaluated via microglia density, location and activation. • Microglia parameters are shown for whole mouse brain slices co-registered with dose. • Microglia density increases in accordance with the contrast-enhanced volume. • Microglia density increase is mainly attributed to the radiated region. • Periventricular and high dose areas show increased microglia activation and proliferation.

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Dresden (DD01)
2. E050 KKE Strahlentherapie (E050)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2025

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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