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@ARTICLE{Kias:303216,
      author       = {A. Kias$^*$ and M. Schmidt$^*$ and A. E. Hiensch and D.
                      Clauss$^*$ and E. M. Monninkhof and M. Pelaez and J. Belloso
                      and N. Gunasekara and M. G. Sweegers and M. Trevaskis and H.
                      Rundqvist and J. Müller and J. Wiskemann and E. van der
                      Wall and N. K. Aaronson and M. Lachowicz and A.
                      Urruticoechea and E. M. Zopf and W. Bloch and M. M. Stuiver
                      and Y. Wengström and A. M. May and K. Steindorf$^*$},
      title        = {{F}actors {A}ssociated {W}ith {E}mployment and {Q}uality of
                      {W}orking {L}ife in {P}atients {W}ith {M}etastatic {B}reast
                      {C}ancer.},
      journal      = {Cancer medicine},
      volume       = {14},
      number       = {15},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-01567},
      pages        = {e71074},
      year         = {2025},
      note         = {#EA:C110#LA:C110#},
      abstract     = {As survival of patients with metastatic breast cancer (MBC)
                      improves, their work situation is gaining importance. The
                      aim of the current study was to identify factors associated
                      with work status and quality of working life (QWL) in
                      patients with MBC. Additionally, we investigated the effects
                      of an exercise intervention on work status.Within the
                      multinational PREFERABLE-EFFECT exercise trial, 287 patients
                      with MBC of working age (18-65 years) reported on their
                      working situation over 9 months as a secondary endpoint.
                      Among a subgroup of participants, QWL was assessed by the
                      Quality of Working Life Questionnaire for Cancer Survivors
                      (QWLQ-CS) (N = 59).At baseline, 157 $(54.7\%)$ participants
                      were employed, of whom one-third reported having recently
                      reduced their amount of work because of fatigue $(41.7\%),$
                      cognitive problems $(33.3\%),$ or inability to meet work
                      demands $(33.3\%).$ Participants wished for more flexible
                      working hours $(29.2\%)$ and less productivity pressure
                      $(37.5\%).$ Participants were less likely to work if they
                      experienced higher levels of pain (p = 0.014). Among working
                      participants, an academic education and higher levels of
                      psychological distress were associated with a higher number
                      of working hours (all p < 0.05). Fatigue, an academic
                      education, and performing mentally strenuous tasks at work
                      were negatively associated with QWL (all p < 0.05). The
                      exercise intervention did not affect the number of hours
                      worked during the study.Symptom management might be
                      important for patients' ability to work. To help patients
                      stay employed and improve QWL, employers should consider
                      offering more flexible work arrangements and adapting to
                      their employees' changing needs and abilities.The
                      PREFERABLE-EFFECT trial was registered with
                      ClinicalTrials.gov on October 9, 2019 (NCT04120298).},
      keywords     = {employment (Other) / exercise (Other) / fatigue (Other) /
                      metastatic breast cancer (Other) / pain (Other) / quality of
                      working life (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40714912},
      pmc          = {pmc:PMC12296696},
      doi          = {10.1002/cam4.71074},
      url          = {https://inrepo02.dkfz.de/record/303216},
}