Journal Article

DKFZ-2025-01567

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Factors Associated With Employment and Quality of Working Life in Patients With Metastatic Breast Cancer.

Kias, A. (First author)DKFZ* ; Schmidt, M.DKFZ* ; Hiensch, A. E. ; Clauss, D.DKFZ* ; Monninkhof, E. M. ; Pelaez, M. ; Belloso, J. ; Gunasekara, N. ; Sweegers, M. G. ; Trevaskis, M. ; Rundqvist, H. ; Müller, J. ; Wiskemann, J. ; van der Wall, E. ; Aaronson, N. K. ; Lachowicz, M. ; Urruticoechea, A. ; Zopf, E. M. ; Bloch, W. ; Stuiver, M. M. ; Wengström, Y. ; May, A. M. ; Steindorf, K. (Last author)DKFZ*

2025
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/cam4.71074

Abstract: As survival of patients with metastatic breast cancer (MBC) improves, their work situation is gaining importance. The aim of the current study was to identify factors associated with work status and quality of working life (QWL) in patients with MBC. Additionally, we investigated the effects of an exercise intervention on work status.Within the multinational PREFERABLE-EFFECT exercise trial, 287 patients with MBC of working age (18-65 years) reported on their working situation over 9 months as a secondary endpoint. Among a subgroup of participants, QWL was assessed by the Quality of Working Life Questionnaire for Cancer Survivors (QWLQ-CS) (N = 59).At baseline, 157 (54.7%) participants were employed, of whom one-third reported having recently reduced their amount of work because of fatigue (41.7%), cognitive problems (33.3%), or inability to meet work demands (33.3%). Participants wished for more flexible working hours (29.2%) and less productivity pressure (37.5%). Participants were less likely to work if they experienced higher levels of pain (p = 0.014). Among working participants, an academic education and higher levels of psychological distress were associated with a higher number of working hours (all p < 0.05). Fatigue, an academic education, and performing mentally strenuous tasks at work were negatively associated with QWL (all p < 0.05). The exercise intervention did not affect the number of hours worked during the study.Symptom management might be important for patients' ability to work. To help patients stay employed and improve QWL, employers should consider offering more flexible work arrangements and adapting to their employees' changing needs and abilities.The PREFERABLE-EFFECT trial was registered with ClinicalTrials.gov on October 9, 2019 (NCT04120298).

Keyword(s): employment ; exercise ; fatigue ; metastatic breast cancer ; pain ; quality of working life

Note: #EA:C110#LA:C110#

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Contributing Institute(s):

1. Bewegung, Krebsprävention und Survivorship (C110)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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