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000303229 1001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b0$$eFirst author$$udkfz
000303229 245__ $$aSex Disparities and Female Reproductive and Hormonal Factors Associated with Risk of Pancreatic Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.
000303229 260__ $$aBasel$$bMDPI$$c2025
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000303229 520__ $$aBackground/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to ≤5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus ≤2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect.
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000303229 650_7 $$2Other$$aEPIC study
000303229 650_7 $$2Other$$ahormonal factors
000303229 650_7 $$2Other$$apancreatic cancer
000303229 650_7 $$2Other$$areproductive factors
000303229 650_7 $$2Other$$asex differences
000303229 650_7 $$2Other$$awomen
000303229 7001_ $$0P:(DE-He78)695e2f977f4904bd23f3d05c0b5ac84a$$aDutta, Srimanti$$b1$$udkfz
000303229 7001_ $$aRasokat, Anna$$b2
000303229 7001_ $$00000-0003-3979-9553$$aArchibugi, Livia$$b3
000303229 7001_ $$00000-0002-0019-8753$$aCapurso, Gabriele$$b4
000303229 7001_ $$aPeduzzi, Giulia$$b5
000303229 7001_ $$aGentiluomo, Manuel$$b6
000303229 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b7$$udkfz
000303229 7001_ $$aEriksen, Anne Kirstine$$b8
000303229 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b9
000303229 7001_ $$00000-0003-0481-2893$$aDahm, Christina C$$b10
000303229 7001_ $$00000-0002-2943-6786$$aTruong, Therese$$b11
000303229 7001_ $$aCanonico, Marianne$$b12
000303229 7001_ $$00000-0002-8532-456X$$aLaouali, Nasser$$b13
000303229 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b14
000303229 7001_ $$aTumino, Rosario$$b15
000303229 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b16
000303229 7001_ $$aAgnoli, Claudia$$b17
000303229 7001_ $$00000-0003-2304-5378$$aDansero, Lucia$$b18
000303229 7001_ $$aPanico, Salvatore$$b19
000303229 7001_ $$00000-0003-1493-4288$$aCrous-Bou, Marta$$b20
000303229 7001_ $$00000-0002-0428-2426$$aMolina-Montes, Esther$$b21
000303229 7001_ $$00000-0002-0226-5358$$aDorronsoro, Ane$$b22
000303229 7001_ $$aChirlaque, María-Dolores$$b23
000303229 7001_ $$00000-0001-9242-6364$$aGuevara, Marcela$$b24
000303229 7001_ $$aButt, Salma Tunå$$b25
000303229 7001_ $$00000-0002-7516-9543$$aSund, Malin$$b26
000303229 7001_ $$aChristakoudi, Sofia$$b27
000303229 7001_ $$00000-0002-0442-3284$$aAglago, Elom K$$b28
000303229 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b29
000303229 7001_ $$aGunter, Marc$$b30
000303229 7001_ $$aCampa, Daniele$$b31
000303229 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b32$$eLast author$$udkfz
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