Journal Article

DKFZ-2025-01580

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sex Disparities and Female Reproductive and Hormonal Factors Associated with Risk of Pancreatic Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.

Katzke, V. (First author)DKFZ* ; Dutta, S.DKFZ* ; Rasokat, A. ; Archibugi, L. ; Capurso, G. ; Peduzzi, G. ; Gentiluomo, M. ; Canzian, F.DKFZ* ; Eriksen, A. K. ; Tjønneland, A. ; Dahm, C. C. ; Truong, T. ; Canonico, M. ; Laouali, N. ; Schulze, M. B. ; Tumino, R. ; Masala, G. ; Agnoli, C. ; Dansero, L. ; Panico, S. ; Crous-Bou, M. ; Molina-Montes, E. ; Dorronsoro, A. ; Chirlaque, M.-D. ; Guevara, M. ; Butt, S. T. ; Sund, M. ; Christakoudi, S. ; Aglago, E. K. ; Weiderpass, E. ; Gunter, M. ; Campa, D. ; Kaaks, R. (Last author)DKFZ*

2025
MDPI Basel

This record in other databases:  

Please use a persistent id in citations: doi:10.3390/cancers17142275

Abstract: Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to ≤5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus ≤2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect.

Keyword(s): EPIC study ; hormonal factors ; pancreatic cancer ; reproductive factors ; sex differences ; women

Note: #EA:C020#LA:C020#

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Contributing Institute(s):

1. Epidemiologie von Krebs (C020)
2. Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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