% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Katzke:303229,
      author       = {V. Katzke$^*$ and S. Dutta$^*$ and A. Rasokat and L.
                      Archibugi and G. Capurso and G. Peduzzi and M. Gentiluomo
                      and F. Canzian$^*$ and A. K. Eriksen and A. Tjønneland and
                      C. C. Dahm and T. Truong and M. Canonico and N. Laouali and
                      M. B. Schulze and R. Tumino and G. Masala and C. Agnoli and
                      L. Dansero and S. Panico and M. Crous-Bou and E.
                      Molina-Montes and A. Dorronsoro and M.-D. Chirlaque and M.
                      Guevara and S. T. Butt and M. Sund and S. Christakoudi and
                      E. K. Aglago and E. Weiderpass and M. Gunter and D. Campa
                      and R. Kaaks$^*$},
      title        = {{S}ex {D}isparities and {F}emale {R}eproductive and
                      {H}ormonal {F}actors {A}ssociated with {R}isk of
                      {P}ancreatic {C}ancer in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition ({EPIC})
                      {C}ohort.},
      journal      = {Cancers},
      volume       = {17},
      number       = {14},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2025-01580},
      pages        = {2275},
      year         = {2025},
      note         = {#EA:C020#LA:C020#},
      abstract     = {Background/Objectives: Worldwide, men experience a higher
                      incidence of pancreatic cancer (PC) than women. Methods: To
                      increase understanding of the underlying reasons for this
                      sex-related difference, we analysed general and sex-related
                      risk factors for PC in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) cohort
                      (women/men No. = 293,682/136,728; 717/577 PC-cases).
                      Results: Cox proportional hazards models showed a 1.31-fold
                      higher risk of developing PC for men compared to women (HR,
                      $95\%$ CI 1.15-1.49) after adjustment for age, smoking
                      history, BMI, diabetes, and alcohol consumption.
                      Associations of PC with established risk factors did not
                      differ between men and women, with the exception of a
                      greater risk of PC among women with greater attained body
                      height, meat consumption and cigarettes smoked (1.12
                      (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42
                      (1.27-1.59) per 10/d; respectively). Among child-bearing
                      women, long cumulative duration of breastfeeding was
                      inversely associated with risk of PC (HR 0.74, $95\%$ CI
                      0.61-0.89) for >5.7 months of breastfeeding (median)
                      relative to ≤5.7 months and among HRT users, cumulative
                      duration of HRT use was inversely associated with PC risk
                      (HR 0.71, $95\%$ CI 0.53-0.95, >2.4 versus ≤2.4 years).
                      Further reproductive and hormonal factors, such as age at
                      menarche, number of full-term pregnancies, age at menopause,
                      or use of oral contraceptives, were not significantly
                      associated with PC risk. Conclusions: Pooled analyses of
                      large cohort studies are needed to confirm these results,
                      and detailed data on the type and intensity of HRT are
                      required to better evaluate its effect.},
      keywords     = {EPIC study (Other) / hormonal factors (Other) / pancreatic
                      cancer (Other) / reproductive factors (Other) / sex
                      differences (Other) / women (Other)},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40723159},
      doi          = {10.3390/cancers17142275},
      url          = {https://inrepo02.dkfz.de/record/303229},
}