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| 024 | 7 | _ | |a 10.3390/cancers17142275 |2 doi |
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| 037 | _ | _ | |a DKFZ-2025-01580 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Katzke, Verena |0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Sex Disparities and Female Reproductive and Hormonal Factors Associated with Risk of Pancreatic Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort. |
| 260 | _ | _ | |a Basel |c 2025 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1753941073_19395 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:C020#LA:C020# |
| 520 | _ | _ | |a Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results: Cox proportional hazards models showed a 1.31-fold higher risk of developing PC for men compared to women (HR, 95% CI 1.15-1.49) after adjustment for age, smoking history, BMI, diabetes, and alcohol consumption. Associations of PC with established risk factors did not differ between men and women, with the exception of a greater risk of PC among women with greater attained body height, meat consumption and cigarettes smoked (1.12 (1.05-1.19) per 5 cm, 1.18 (1.02-1.36) per 100 g/d, 1.42 (1.27-1.59) per 10/d; respectively). Among child-bearing women, long cumulative duration of breastfeeding was inversely associated with risk of PC (HR 0.74, 95% CI 0.61-0.89) for >5.7 months of breastfeeding (median) relative to ≤5.7 months and among HRT users, cumulative duration of HRT use was inversely associated with PC risk (HR 0.71, 95% CI 0.53-0.95, >2.4 versus ≤2.4 years). Further reproductive and hormonal factors, such as age at menarche, number of full-term pregnancies, age at menopause, or use of oral contraceptives, were not significantly associated with PC risk. Conclusions: Pooled analyses of large cohort studies are needed to confirm these results, and detailed data on the type and intensity of HRT are required to better evaluate its effect. |
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| 650 | _ | 7 | |a EPIC study |2 Other |
| 650 | _ | 7 | |a hormonal factors |2 Other |
| 650 | _ | 7 | |a pancreatic cancer |2 Other |
| 650 | _ | 7 | |a reproductive factors |2 Other |
| 650 | _ | 7 | |a sex differences |2 Other |
| 650 | _ | 7 | |a women |2 Other |
| 700 | 1 | _ | |a Dutta, Srimanti |0 P:(DE-He78)695e2f977f4904bd23f3d05c0b5ac84a |b 1 |u dkfz |
| 700 | 1 | _ | |a Rasokat, Anna |b 2 |
| 700 | 1 | _ | |a Archibugi, Livia |0 0000-0003-3979-9553 |b 3 |
| 700 | 1 | _ | |a Capurso, Gabriele |0 0000-0002-0019-8753 |b 4 |
| 700 | 1 | _ | |a Peduzzi, Giulia |b 5 |
| 700 | 1 | _ | |a Gentiluomo, Manuel |b 6 |
| 700 | 1 | _ | |a Canzian, Federico |0 P:(DE-He78)5323704270b6393dcea70186ffd86bca |b 7 |u dkfz |
| 700 | 1 | _ | |a Eriksen, Anne Kirstine |b 8 |
| 700 | 1 | _ | |a Tjønneland, Anne |0 0000-0003-4385-2097 |b 9 |
| 700 | 1 | _ | |a Dahm, Christina C |0 0000-0003-0481-2893 |b 10 |
| 700 | 1 | _ | |a Truong, Therese |0 0000-0002-2943-6786 |b 11 |
| 700 | 1 | _ | |a Canonico, Marianne |b 12 |
| 700 | 1 | _ | |a Laouali, Nasser |0 0000-0002-8532-456X |b 13 |
| 700 | 1 | _ | |a Schulze, Matthias B |0 0000-0002-0830-5277 |b 14 |
| 700 | 1 | _ | |a Tumino, Rosario |b 15 |
| 700 | 1 | _ | |a Masala, Giovanna |0 0000-0002-5758-9069 |b 16 |
| 700 | 1 | _ | |a Agnoli, Claudia |b 17 |
| 700 | 1 | _ | |a Dansero, Lucia |0 0000-0003-2304-5378 |b 18 |
| 700 | 1 | _ | |a Panico, Salvatore |b 19 |
| 700 | 1 | _ | |a Crous-Bou, Marta |0 0000-0003-1493-4288 |b 20 |
| 700 | 1 | _ | |a Molina-Montes, Esther |0 0000-0002-0428-2426 |b 21 |
| 700 | 1 | _ | |a Dorronsoro, Ane |0 0000-0002-0226-5358 |b 22 |
| 700 | 1 | _ | |a Chirlaque, María-Dolores |b 23 |
| 700 | 1 | _ | |a Guevara, Marcela |0 0000-0001-9242-6364 |b 24 |
| 700 | 1 | _ | |a Butt, Salma Tunå |b 25 |
| 700 | 1 | _ | |a Sund, Malin |0 0000-0002-7516-9543 |b 26 |
| 700 | 1 | _ | |a Christakoudi, Sofia |b 27 |
| 700 | 1 | _ | |a Aglago, Elom K |0 0000-0002-0442-3284 |b 28 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |0 0000-0003-2237-0128 |b 29 |
| 700 | 1 | _ | |a Gunter, Marc |b 30 |
| 700 | 1 | _ | |a Campa, Daniele |b 31 |
| 700 | 1 | _ | |a Kaaks, Rudolf |0 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a |b 32 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.3390/cancers17142275 |g Vol. 17, no. 14, p. 2275 - |0 PERI:(DE-600)2527080-1 |n 14 |p 2275 |t Cancers |v 17 |y 2025 |x 2072-6694 |
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