TY  - JOUR
AU  - Haenlin, Julie
AU  - Schulze, Almut
TI  - A cholesterol-dependent switch controls organ-specific metastasis in pancreatic cancer.
JO  - Developmental cell
VL  - 60
IS  - 15
SN  - 1534-5807
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2025-01633
SP  - 2029 - 2031
PY  - 2025
N1  - #EA:A410#LA:A410# / Spotlight
AB  - As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer cells to different environments by regulating cholesterol metabolism.
KW  - Pancreatic Neoplasms: pathology
KW  - Pancreatic Neoplasms: metabolism
KW  - Humans
KW  - Cholesterol: metabolism
KW  - Neoplasm Metastasis
KW  - Animals
KW  - Proprotein Convertase 9
KW  - Proprotein Convertases: metabolism
KW  - Tumor Microenvironment
KW  - Organ Specificity
KW  - Cholesterol (NLM Chemicals)
KW  - Proprotein Convertase 9 (NLM Chemicals)
KW  - PCSK9 protein, human (NLM Chemicals)
KW  - Proprotein Convertases (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40763707
DO  - DOI:10.1016/j.devcel.2025.07.001
UR  - https://inrepo02.dkfz.de/record/303393
ER  -