Journal Article

DKFZ-2025-01633

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A cholesterol-dependent switch controls organ-specific metastasis in pancreatic cancer.

Haenlin, J. (First author)DKFZ* ; Schulze, A. (Last author)DKFZ*

2025
Cell Press Cambridge, Mass.

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Please use a persistent id in citations: doi:10.1016/j.devcel.2025.07.001

Abstract: As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer cells to different environments by regulating cholesterol metabolism.

Keyword(s): Pancreatic Neoplasms: pathology (MeSH) ; Pancreatic Neoplasms: metabolism (MeSH) ; Humans (MeSH) ; Cholesterol: metabolism (MeSH) ; Neoplasm Metastasis (MeSH) ; Animals (MeSH) ; Proprotein Convertase 9 (MeSH) ; Proprotein Convertases: metabolism (MeSH) ; Tumor Microenvironment (MeSH) ; Organ Specificity (MeSH) ; Cholesterol ; Proprotein Convertase 9 ; PCSK9 protein, human ; Proprotein Convertases

Note: #EA:A410#LA:A410# / Spotlight

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Contributing Institute(s):

1. Metabolismus und Microenvironment (A410)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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