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@ARTICLE{Haenlin:303393,
      author       = {J. Haenlin$^*$ and A. Schulze$^*$},
      title        = {{A} cholesterol-dependent switch controls organ-specific
                      metastasis in pancreatic cancer.},
      journal      = {Developmental cell},
      volume       = {60},
      number       = {15},
      issn         = {1534-5807},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-01633},
      pages        = {2029 - 2031},
      year         = {2025},
      note         = {#EA:A410#LA:A410# / Spotlight},
      abstract     = {As different organs offer distinct chemical
                      microenvironments, cancer cells require unique metabolic
                      adaptation to colonize distant sites. In a recent issue of
                      Nature, Rademaker et al. identify PCSK9 as a predictive
                      factor for metastatic colonization of different organs,
                      showing adaptation of cancer cells to different environments
                      by regulating cholesterol metabolism.},
      keywords     = {Pancreatic Neoplasms: pathology / Pancreatic Neoplasms:
                      metabolism / Humans / Cholesterol: metabolism / Neoplasm
                      Metastasis / Animals / Proprotein Convertase 9 / Proprotein
                      Convertases: metabolism / Tumor Microenvironment / Organ
                      Specificity / Cholesterol (NLM Chemicals) / Proprotein
                      Convertase 9 (NLM Chemicals) / PCSK9 protein, human (NLM
                      Chemicals) / Proprotein Convertases (NLM Chemicals)},
      cin          = {A410},
      ddc          = {610},
      cid          = {I:(DE-He78)A410-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40763707},
      doi          = {10.1016/j.devcel.2025.07.001},
      url          = {https://inrepo02.dkfz.de/record/303393},
}