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024 7 _ |a 10.1016/j.devcel.2025.07.001
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037 _ _ |a DKFZ-2025-01633
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Haenlin, Julie
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245 _ _ |a A cholesterol-dependent switch controls organ-specific metastasis in pancreatic cancer.
260 _ _ |a Cambridge, Mass.
|c 2025
|b Cell Press
336 7 _ |a article
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520 _ _ |a As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer cells to different environments by regulating cholesterol metabolism.
536 _ _ |a 311 - Zellbiologie und Tumorbiologie (POF4-311)
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650 _ 7 |a Cholesterol
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650 _ 7 |a Proprotein Convertase 9
|0 EC 3.4.21.-
|2 NLM Chemicals
650 _ 7 |a PCSK9 protein, human
|0 EC 3.4.21.-
|2 NLM Chemicals
650 _ 7 |a Proprotein Convertases
|0 EC 3.4.21.-
|2 NLM Chemicals
650 _ 2 |a Pancreatic Neoplasms: pathology
|2 MeSH
650 _ 2 |a Pancreatic Neoplasms: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Cholesterol: metabolism
|2 MeSH
650 _ 2 |a Neoplasm Metastasis
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Proprotein Convertase 9
|2 MeSH
650 _ 2 |a Proprotein Convertases: metabolism
|2 MeSH
650 _ 2 |a Tumor Microenvironment
|2 MeSH
650 _ 2 |a Organ Specificity
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700 1 _ |a Schulze, Almut
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773 _ _ |a 10.1016/j.devcel.2025.07.001
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