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@ARTICLE{Anker:303406,
      author       = {M. S. Anker and M. S. Khan and A. Nikolski and J. Porthun
                      and M. S. Arshad and S. Hadzibegovic and A. Lena and L.
                      Kretzler and J. L. Hella and M. Witkowski and K. Rieger$^*$
                      and J. Ahn$^*$ and D. P. Modest$^*$ and U. Keller$^*$ and L.
                      Bullinger$^*$ and M. Totzeck and A. A. Mahabadi and T.
                      Rassaf and N. Buchmann and P. Attanasio and T. Zeller and M.
                      Karakas and C. G. Tocchetti and U. Wilkenshoff and J. G. F.
                      Cleland and S. von Haehling and J. Butler and U. Landmesser},
      title        = {{C}linical and echocardiographic phenotype of cardiac
                      wasting in patients with advanced cancer.},
      journal      = {European journal of heart failure},
      volume       = {27},
      number       = {11},
      issn         = {1388-9842},
      address      = {Oxford},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-01642},
      pages        = {2130-2140},
      year         = {2025},
      note         = {2025 Nov;27(11):2130-2140},
      abstract     = {Cardiac wasting-associated cardiomyopathy in patients with
                      advanced cancer is characterized by loss of left ventricular
                      (LV) mass and independently associated with poor prognosis.
                      Better understanding of this very prevalent cardiomyopathy
                      is urgently needed.Overall, 398 patients with active, mostly
                      advanced cancer without significant cardiovascular disease
                      (mean LV ejection fraction [LVEF] 64.3 ± $0.2\%)$ or active
                      infection were prospectively examined (mean age 60 ± 1
                      years, $50\%$ women, body mass index 25.0 ± 0.2 kg/m2,
                      $26\%$ cachectic). Patients were categorized and compared by
                      quartiles of LV mass/height2. LVEF, global longitudinal
                      strain (GLS), and anticancer therapy naive status were
                      similar across quartiles. Patients in Q1 (lowest LV mass
                      quartile) were younger, more likely cachectic, had lower:
                      BMI, 10-step stair-climbing power, tricuspid annular plane
                      systolic excursion (TAPSE), stroke volume, cardiac output,
                      and higher heart rate. In repeat follow-up assessments after
                      140 ± 8 days (n = 143), LVEF, TAPSE, LV mass, left atrial
                      volume, and GLS were found reduced (all p ≤ 0.002). Only
                      in those with above-median LV mass at baseline, cardiac
                      output and heart rate increased during follow-up - in those
                      with below-median LV mass, mitral E/A decreased.Patients
                      with advanced cancer with low LV mass have a distinct
                      phenotype characterized by lower cardiac chamber volumes,
                      stroke volume, and cardiac output, but normal LVEF and GLS
                      that may be the distinct feature of cardiac
                      wasting-associated cardiomyopathy.},
      keywords     = {Cancer (Other) / Cardiac wasting cardiomyopathy (Other) /
                      Echocardiography (Other) / Left ventricular mass (Other) /
                      Pathophysiology (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40767389},
      doi          = {10.1002/ejhf.3744},
      url          = {https://inrepo02.dkfz.de/record/303406},
}