Journal Article

DKFZ-2025-01642

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Clinical and echocardiographic phenotype of cardiac wasting in patients with advanced cancer.

Anker, M. S. ; Khan, M. S. ; Nikolski, A. ; Porthun, J. ; Arshad, M. S. ; Hadzibegovic, S. ; Lena, A. ; Kretzler, L. ; Hella, J. L. ; Witkowski, M. ; Rieger, K.DKFZ* ; Ahn, J.DKFZ* ; Modest, D. P.DKFZ* ; Keller, U.DKFZ* ; Bullinger, L.DKFZ* ; Totzeck, M. ; Mahabadi, A. A. ; Rassaf, T. ; Buchmann, N. ; Attanasio, P. ; Zeller, T. ; Karakas, M. ; Tocchetti, C. G. ; Wilkenshoff, U. ; Cleland, J. G. F. ; von Haehling, S. ; Butler, J. ; Landmesser, U.

2025
Wiley Oxford

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Please use a persistent id in citations: doi:10.1002/ejhf.3744

Abstract: Cardiac wasting-associated cardiomyopathy in patients with advanced cancer is characterized by loss of left ventricular (LV) mass and independently associated with poor prognosis. Better understanding of this very prevalent cardiomyopathy is urgently needed.Overall, 398 patients with active, mostly advanced cancer without significant cardiovascular disease (mean LV ejection fraction [LVEF] 64.3 ± 0.2%) or active infection were prospectively examined (mean age 60 ± 1 years, 50% women, body mass index 25.0 ± 0.2 kg/m2, 26% cachectic). Patients were categorized and compared by quartiles of LV mass/height2. LVEF, global longitudinal strain (GLS), and anticancer therapy naive status were similar across quartiles. Patients in Q1 (lowest LV mass quartile) were younger, more likely cachectic, had lower: BMI, 10-step stair-climbing power, tricuspid annular plane systolic excursion (TAPSE), stroke volume, cardiac output, and higher heart rate. In repeat follow-up assessments after 140 ± 8 days (n = 143), LVEF, TAPSE, LV mass, left atrial volume, and GLS were found reduced (all p ≤ 0.002). Only in those with above-median LV mass at baseline, cardiac output and heart rate increased during follow-up - in those with below-median LV mass, mitral E/A decreased.Patients with advanced cancer with low LV mass have a distinct phenotype characterized by lower cardiac chamber volumes, stroke volume, and cardiac output, but normal LVEF and GLS that may be the distinct feature of cardiac wasting-associated cardiomyopathy.

Keyword(s): Cancer ; Cardiac wasting cardiomyopathy ; Echocardiography ; Left ventricular mass ; Pathophysiology

Note: 2025 Nov;27(11):2130-2140

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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