Journal Article

DKFZ-2025-01654

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A FABulous Couple: Adding PHENotype to GENotype Improves HMA/VEN Response Prediction in AML.

Renders, S. (First author)DKFZ* ; Waclawiczek, A.DKFZ* ; Trumpp, A. (Last author)DKFZ*

2025
American Association for Cancer Research Philadelphia, PA

Abstract: In a large retrospective multicenter study of patients with acute myeloid leukemia treated with hypomethylating agents and venetoclax, Lachowiez and colleagues examine the interplay among genetic mutations, disease phenotype, and clinical outcomes. They show that within genetic subgroups-particularly NPM1 wild-type cases-monocytic differentiation is linked to poor treatment response and inferior long-term prognosis, adding a phenotypic layer to genetics-based response prediction. See related article by Lachowiez et al., p. XX.

Note: DKFZ-ZMBH Alliance / #EA:A010#LA:A010# /2025 Sep 3;6(5):403-405

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Contributing Institute(s):

1. A010 Stammzellen und Krebs (A010)
2. DKTK HD zentral (HD01)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; IF >= 10 ; JCR ; SCOPUS ; Web of Science Core Collection

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