%0 Journal Article
%A Hesterberg, Rebecca S
%A Davis, Joshua T
%A Handoo, Komal J
%A Elmarsafawi, Aya G
%A Augello, Anthony C
%A Cheng, Chia-Ho
%A Atkins, Reginald
%A Lee, Dae Hyun
%A Yang, Chunying
%A Yao, Jiqiang
%A Patel, Krishna R
%A Mediavilla-Varela, Melanie
%A Pinilla-Ibarz, Javier
%A Soto-Palma, Carolina
%A Locke, Frederick L
%A Song, Xiaofei
%A Wang, Xuefeng
%A Berglund, Anders E
%A Rodriguez, Paulo C
%A Knittel, Gero
%A Flümann, Ruth
%A Reinhardt, Hans Christian
%A Shaw, Timothy I
%A Yu, Xiaoqing
%A Niedernhofer, Laura J
%A Cleveland, John L
%T Lymphoma accelerates T cell and tissue aging.
%J Cancer cell
%V nn
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2025-01756
%P nn
%D 2025
%Z epub
%X The combined effects of aging and cancer on immune cells were investigated in young versus aged mice harboring B cell lymphoma, and in T cells from young and aged B cell lymphoma patients. These analyses revealed that lymphoma alone is sufficient to trigger transcriptional, epigenetic, and phenotypic alterations in young T cells that manifest in aged T cells. In contrast, aged T cells are largely resistant to lymphoma-induced changes. Pathway analyses revealed open chromatin regions and genes controlling iron homeostasis are induced by both lymphoma and aging, and lymphoma-experienced and aged T cells have increased iron pools and are resistant to ferroptosis. Furthermore, both aged and lymphoma-experienced T cells have defects in proteostasis. B cell lymphoma also accelerates aging of other tissues, as evidenced by elevated expression of Cdkn2a and Tnfa. Finally, some lymphoma-induced aging phenotypes are reversible whereas others are fixed, indicating opportunities for improving some cancer-associated aging comorbidities.
%K B cell lymphoma (Other)
%K NK cell (Other)
%K T cell (Other)
%K aging (Other)
%K ferroptosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40845845
%R 10.1016/j.ccell.2025.07.023
%U https://inrepo02.dkfz.de/record/304088