Journal Article

DKFZ-2025-01756

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lymphoma accelerates T cell and tissue aging.

Hesterberg, R. S. ; Davis, J. T. ; Handoo, K. J. ; Elmarsafawi, A. G. ; Augello, A. C. ; Cheng, C.-H. ; Atkins, R. ; Lee, D. H. ; Yang, C. ; Yao, J. ; Patel, K. R. ; Mediavilla-Varela, M. ; Pinilla-Ibarz, J. ; Soto-Palma, C. ; Locke, F. L. ; Song, X. ; Wang, X. ; Berglund, A. E. ; Rodriguez, P. C. ; Knittel, G.DKFZ* ; Flümann, R. ; Reinhardt, H. C.DKFZ* ; Shaw, T. I. ; Yu, X. ; Niedernhofer, L. J. ; Cleveland, J. L.

2025
Cell Press Cambridge, Mass.

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Please use a persistent id in citations: doi:10.1016/j.ccell.2025.07.023

Abstract: The combined effects of aging and cancer on immune cells were investigated in young versus aged mice harboring B cell lymphoma, and in T cells from young and aged B cell lymphoma patients. These analyses revealed that lymphoma alone is sufficient to trigger transcriptional, epigenetic, and phenotypic alterations in young T cells that manifest in aged T cells. In contrast, aged T cells are largely resistant to lymphoma-induced changes. Pathway analyses revealed open chromatin regions and genes controlling iron homeostasis are induced by both lymphoma and aging, and lymphoma-experienced and aged T cells have increased iron pools and are resistant to ferroptosis. Furthermore, both aged and lymphoma-experienced T cells have defects in proteostasis. B cell lymphoma also accelerates aging of other tissues, as evidenced by elevated expression of Cdkn2a and Tnfa. Finally, some lymphoma-induced aging phenotypes are reversible whereas others are fixed, indicating opportunities for improving some cancer-associated aging comorbidities.

Keyword(s): B cell lymphoma ; NK cell ; T cell ; aging ; ferroptosis

Note: 2025 Oct 13;43(10):1917-1936.e8

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Essen/Düsseldorf (ED01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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