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@ARTICLE{Mok:304462,
      author       = {Y. Mok and A. Surapaneni and Y. Sang and J. Coresh and M.
                      E. Grams and K. Matsushita and S. H. Ballew and N. Alencar
                      de Pinho and J. Ärnlöv and S. M. Barreto and S. Bell and
                      H. Brenner$^*$ and J.-J. Carrero and R. Chinnadurai and E.
                      Ciemins and R. T. Gansevoort and S. K. Jassal and K. J. Jung
                      and H. L. Kirchner and T. Konta and C. P. Kovesdy and L. Luo
                      and K. Pandit and M. Rahman and C. Robinson-Cohen and C.
                      Sabanayagam and U. T. Schultheiss and M. Shlipak and N.
                      Staplin and M. Tonelli and A. Y. Wang and C.-P. Wen and M.
                      Woodward and J. S. Lees},
      collaboration = {C. P. Consortium},
      othercontributors = {K. Harris and H. Arima and J. Chalmers and M. Grams and E.
                          Akwo and J. He and A. Lloyd and N. Alencar de Pinho and M.
                          Metzger and B. Stengel and A. Hamroun and Z. Massy and P.
                          Rao and G. Sosa and V. Shah and J. Hsu and A. Vigo and J. G.
                          Mill and P. Lotufo and S. Canhada and B. Schöttker$^*$ and
                          H. Stocker$^*$ and D. Rothenbacher and M. P. Schneider and
                          A. Köttgen and H. Meiselbach and K.-U. Eckardt and J. Green
                          and A. R. Chang and G. Singh and E. Lambourg and S.
                          Livingstone and C. Palmer and E. Pearson and S. H. Jee and
                          H. Kimm and R. Katz and C. Flaherty and J. Mohl and L. M.
                          Kieneker and S. J. Bakker and B. van der Vegt and R. A. de
                          Boer and J. Bergstrom and J. Ix and K. Sumida and P.
                          Shrestha and C.-Y. Cheng and T. Y. Wong and P. Thyagarajan
                          and W. Herrington and M. J. Landray and C. Baigent and P.
                          Kalra and D. Green and S. Sinha and J. Ritchie and M.-K.
                          Tsai and J. Lees and A. Larsson and V. Giedraitis and A. S.
                          Levey and D. Nitsch and M. G. Shlipak},
      title        = {{C}hronic kidney disease and incident cancer risk: an
                      individual participant data meta-analysis.},
      journal      = {British journal of cancer},
      volume       = {nn},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2025-01855},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Studies examining the association of chronic kidney disease
                      (CKD) with cancer risk have demonstrated conflicting
                      results.This was an individual participant data
                      meta-analysis including 54 international cohorts
                      contributing to the CKD Prognosis Consortium. Included
                      cohorts had data on albuminuria [urine albumin-to-creatinine
                      ratio (ACR)], estimated glomerular filtration rate (eGFR),
                      overall and site-specific cancer incidence, and established
                      risk factors for cancer. Included participants were aged 18
                      years or older, without previous cancer or kidney
                      failure.Among 1,319,308 individuals, the incidence rate of
                      overall cancer was 17.3 per 1000 person-years. Higher ACR
                      was positively associated with cancer risk [adjusted hazard
                      ratio 1.08 $(95\%$ CI 1.06-1.10) per 8-fold increase in
                      ACR]. No association of eGFR with overall cancer risk was
                      seen. For site-specific cancers, lower eGFR was associated
                      with urological cancer and multiple myeloma, whereas higher
                      ACR was associated with many cancer types (kidney,
                      head/neck, colorectal, liver, pancreas, bile duct, stomach,
                      larynx, lung, hemolymphatic, leukaemia, and multiple
                      myeloma). Results were similar in a 1-year landmark
                      analysis.Albuminuria, but not necessarily eGFR, was
                      independently associated with the subsequent risk of cancer.
                      Our results warrant an investigation into mechanisms that
                      explain the link between albuminuria and cancer.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40914744},
      doi          = {10.1038/s41416-025-03140-z},
      url          = {https://inrepo02.dkfz.de/record/304462},
}