Journal Article

DKFZ-2025-01855

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis.

Mok, Y. ; Surapaneni, A. ; Sang, Y. ; Coresh, J. ; Grams, M. E. ; Matsushita, K. ; Ballew, S. H. ; Alencar de Pinho, N. ; Ärnlöv, J. ; Barreto, S. M. ; Bell, S. ; Brenner, H.DKFZ* ; Carrero, J.-J. ; Chinnadurai, R. ; Ciemins, E. ; Gansevoort, R. T. ; Jassal, S. K. ; Jung, K. J. ; Kirchner, H. L. ; Konta, T. ; Kovesdy, C. P. ; Luo, L. ; Pandit, K. ; Rahman, M. ; Robinson-Cohen, C. ; Sabanayagam, C. ; Schultheiss, U. T. ; Shlipak, M. ; Staplin, N. ; Tonelli, M. ; Wang, A. Y. ; Wen, C.-P. ; Woodward, M. ; Lees, J. S. ; Consortium, C. P. (Collaboration Author) ; Harris, K. (Contributor) ; Arima, H. (Contributor) ; Chalmers, J. (Contributor) ; Grams, M. (Contributor) ; Akwo, E. (Contributor) ; He, J. (Contributor) ; Lloyd, A. (Contributor) ; Alencar de Pinho, N. (Contributor) ; Metzger, M. (Contributor) ; Stengel, B. (Contributor) ; Hamroun, A. (Contributor) ; Massy, Z. (Contributor) ; Rao, P. (Contributor) ; Sosa, G. (Contributor) ; Shah, V. (Contributor) ; Hsu, J. (Contributor) ; Vigo, A. (Contributor) ; Mill, J. G. (Contributor) ; Lotufo, P. (Contributor) ; Canhada, S. (Contributor) ; Schöttker, B. (Contributor)DKFZ* ; Stocker, H. (Contributor)DKFZ* ; Rothenbacher, D. (Contributor) ; Schneider, M. P. (Contributor) ; Köttgen, A. (Contributor) ; Meiselbach, H. (Contributor) ; Eckardt, K.-U. (Contributor) ; Green, J. (Contributor) ; Chang, A. R. (Contributor) ; Singh, G. (Contributor) ; Lambourg, E. (Contributor) ; Livingstone, S. (Contributor) ; Palmer, C. (Contributor) ; Pearson, E. (Contributor) ; Jee, S. H. (Contributor) ; Kimm, H. (Contributor) ; Katz, R. (Contributor) ; Flaherty, C. (Contributor) ; Mohl, J. (Contributor) ; Kieneker, L. M. (Contributor) ; Bakker, S. J. (Contributor) ; van der Vegt, B. (Contributor) ; de Boer, R. A. (Contributor) ; Bergstrom, J. (Contributor) ; Ix, J. (Contributor) ; Sumida, K. (Contributor) ; Shrestha, P. (Contributor) ; Cheng, C.-Y. (Contributor) ; Wong, T. Y. (Contributor) ; Thyagarajan, P. (Contributor) ; Herrington, W. (Contributor) ; Landray, M. J. (Contributor) ; Baigent, C. (Contributor) ; Kalra, P. (Contributor) ; Green, D. (Contributor) ; Sinha, S. (Contributor) ; Ritchie, J. (Contributor) ; Tsai, M.-K. (Contributor) ; Lees, J. (Contributor) ; Larsson, A. (Contributor) ; Giedraitis, V. (Contributor) ; Levey, A. S. (Contributor) ; Nitsch, D. (Contributor) ; Shlipak, M. G. (Contributor)

2025
Nature Publ. Group Edinburgh

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Please use a persistent id in citations: doi:10.1038/s41416-025-03140-z

Abstract: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis.Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

Note: epub

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Contributing Institute(s):

1. C070 Klinische Epidemiologie der Krebsfrüherkennung (C070)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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