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000304471 1001_ $$aMoore, Amy$$b0
000304471 245__ $$aGenetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.
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000304471 520__ $$aObesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.
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000304471 7001_ $$00000-0003-2419-8536$$aTeras, Lauren R$$b2
000304471 7001_ $$aMachiela, Mitchell J$$b3
000304471 7001_ $$aArias, Joshua$$b4
000304471 7001_ $$aPanagiotou, Orestis A$$b5
000304471 7001_ $$aMonnereau, Alain$$b6
000304471 7001_ $$aDoo, Nicole Wong$$b7
000304471 7001_ $$00000-0001-7556-3869$$aWang, Zhaoming$$b8
000304471 7001_ $$aSlager, Susan L$$b9
000304471 7001_ $$aVermeulen, Roel C H$$b10
000304471 7001_ $$00000-0002-3612-8298$$aVajdic, Claire M$$b11
000304471 7001_ $$aSmedby, Karin E$$b12
000304471 7001_ $$aSpinelli, John J$$b13
000304471 7001_ $$aVijai, Joseph$$b14
000304471 7001_ $$aGiles, Graham G$$b15
000304471 7001_ $$aLink, Brian K$$b16
000304471 7001_ $$aArslan, Alan A$$b17
000304471 7001_ $$aNieters, Alexandra$$b18
000304471 7001_ $$aBracci, Paige M$$b19
000304471 7001_ $$aCamp, Nicola J$$b20
000304471 7001_ $$aSalles, Gilles$$b21
000304471 7001_ $$aCozen, Wendy$$b22
000304471 7001_ $$aHjalgrim, Henrik$$b23
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000304471 7001_ $$aAdami, Hans-Olov$$b25
000304471 7001_ $$aAlbanes, Demetrius$$b26
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000304471 7001_ $$00000-0003-1009-6408$$aBrooks-Wilson, Angela R$$b32
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