Journal Article

DKFZ-2025-01864

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.

Moore, A. ; Kane, E. ; Teras, L. R. ; Machiela, M. J. ; Arias, J. ; Panagiotou, O. A. ; Monnereau, A. ; Doo, N. W. ; Wang, Z. ; Slager, S. L. ; Vermeulen, R. C. H. ; Vajdic, C. M. ; Smedby, K. E. ; Spinelli, J. J. ; Vijai, J. ; Giles, G. G. ; Link, B. K. ; Arslan, A. A. ; Nieters, A. ; Bracci, P. M. ; Camp, N. J. ; Salles, G. ; Cozen, W. ; Hjalgrim, H. ; De Vivo, I. ; Adami, H.-O. ; Albanes, D. ; Becker, N.DKFZ* ; Benavente, Y. ; Bisanzi, S. ; Boffetta, P. ; Brennan, P. ; Brooks-Wilson, A. R. ; Canzian, F.DKFZ* ; Clavel, J. ; Conde, L. ; Cox, D. G. ; Curtin, K. ; Foretova, L. ; Ghesquières, H. ; Glimelius, B. ; Habermann, T. M. ; Hofmann, J. N. ; Lan, Q. ; Liebow, M. ; Lincoln, A. ; Maynadie, M. ; McKay, J. ; Melbye, M. ; Miligi, L. ; Milne, R. L. ; Molina, T. J. ; Morton, L. M. ; North, K. E. ; Offit, K. ; Padoan, M. ; Piro, S. ; Patel, A. V. ; Purdue, M. P. ; Ravichandran, V. ; Riboli, E. ; Severson, R. K. ; Southey, M. C. ; Staines, A. ; Tinker, L. F. ; Travis, R. C. ; Wang, S. S. ; Weiderpass, E. ; Weinstein, S. ; Zheng, T. ; Chanock, S. J. ; Rothman, N. ; Birmann, B. M. ; Cerhan, J. R. ; Berndt, S. I.

2025
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.70039

Abstract: Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.

Note: epub

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Contributing Institute(s):

1. Epidemiologie von Krebs (C020)
2. Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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