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@ARTICLE{Moore:304471,
author = {A. Moore and E. Kane and L. R. Teras and M. J. Machiela and
J. Arias and O. A. Panagiotou and A. Monnereau and N. W. Doo
and Z. Wang and S. L. Slager and R. C. H. Vermeulen and C.
M. Vajdic and K. E. Smedby and J. J. Spinelli and J. Vijai
and G. G. Giles and B. K. Link and A. A. Arslan and A.
Nieters and P. M. Bracci and N. J. Camp and G. Salles and W.
Cozen and H. Hjalgrim and I. De Vivo and H.-O. Adami and D.
Albanes and N. Becker$^*$ and Y. Benavente and S. Bisanzi
and P. Boffetta and P. Brennan and A. R. Brooks-Wilson and
F. Canzian$^*$ and J. Clavel and L. Conde and D. G. Cox and
K. Curtin and L. Foretova and H. Ghesquières and B.
Glimelius and T. M. Habermann and J. N. Hofmann and Q. Lan
and M. Liebow and A. Lincoln and M. Maynadie and J. McKay
and M. Melbye and L. Miligi and R. L. Milne and T. J. Molina
and L. M. Morton and K. E. North and K. Offit and M. Padoan
and S. Piro and A. V. Patel and M. P. Purdue and V.
Ravichandran and E. Riboli and R. K. Severson and M. C.
Southey and A. Staines and L. F. Tinker and R. C. Travis and
S. S. Wang and E. Weiderpass and S. Weinstein and T. Zheng
and S. J. Chanock and N. Rothman and B. M. Birmann and J. R.
Cerhan and S. I. Berndt},
title = {{G}enetically determined body mass index is associated with
diffuse large {B}-cell lymphoma in polygenic and {M}endelian
randomization analyses.},
journal = {International journal of cancer},
volume = {nn},
issn = {0020-7136},
address = {Bognor Regis},
publisher = {Wiley-Liss},
reportid = {DKFZ-2025-01864},
pages = {nn},
year = {2025},
note = {epub},
abstract = {Obesity has been associated with non-Hodgkin lymphoma
(NHL), but the evidence is inconclusive. We examined the
association between genetically determined adiposity and
four common NHL subtypes: diffuse large B-cell lymphoma
(DLBCL), follicular lymphoma, chronic lymphocytic leukemia,
and marginal zone lymphoma, using eight genome-wide
association studies of European ancestry (N = 10,629 cases,
9505 controls) and constructing polygenic scores for body
mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip
ratio adjusted for BMI (WHRadjBMI). Higher genetically
determined BMI was associated with an increased risk of
DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18,
$95\%$ confidence interval $(95\%$ CI): 1.05-1.33, p =
.005]. This finding was consistent with Mendelian
randomization analyses, which demonstrated a similar
increased risk of DLBCL with higher genetically determined
BMI (ORper SD = 1.12, $95\%$ CI: 1.02-1.23, p = .03). No
significant associations were observed with other NHL
subtypes. Our study demonstrates a positive link between a
genetically determined BMI and an increased risk of DLBCL,
providing additional support for increased adiposity as a
risk factor for DLBCL.},
cin = {C020 / C055},
ddc = {610},
cid = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:40910475},
doi = {10.1002/ijc.70039},
url = {https://inrepo02.dkfz.de/record/304471},
}