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| Home > Publications database > Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses. > print |
| 001 | 304471 | ||
| 005 | 20250914022641.0 | ||
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| 100 | 1 | _ | |a Moore, Amy |b 0 |
| 245 | _ | _ | |a Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses. |
| 260 | _ | _ | |a Bognor Regis |c 2025 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a epub |
| 520 | _ | _ | |a Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL. |
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| 700 | 1 | _ | |a Teras, Lauren R |0 0000-0003-2419-8536 |b 2 |
| 700 | 1 | _ | |a Machiela, Mitchell J |b 3 |
| 700 | 1 | _ | |a Arias, Joshua |b 4 |
| 700 | 1 | _ | |a Panagiotou, Orestis A |b 5 |
| 700 | 1 | _ | |a Monnereau, Alain |b 6 |
| 700 | 1 | _ | |a Doo, Nicole Wong |b 7 |
| 700 | 1 | _ | |a Wang, Zhaoming |0 0000-0001-7556-3869 |b 8 |
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| 700 | 1 | _ | |a Camp, Nicola J |b 20 |
| 700 | 1 | _ | |a Salles, Gilles |b 21 |
| 700 | 1 | _ | |a Cozen, Wendy |b 22 |
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