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000304507 1001_ $$aPetry, Philippe$$b0
000304507 245__ $$aEarly microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface.
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000304507 520__ $$aMacrophage progenitors colonize their anatomical niches in the central nervous system (CNS) in distinct pre- and postnatal waves. Microglia progenitors originate from early erythromyeloid progenitors in the yolk sac and enter the murine CNS around embryonic day (E)9.5. While their developmental origin is well established, the molecular mechanisms guiding CNS colonization are not yet resolved. Using transcriptomic and proteomic approaches, we identified potential factors involved in this process. Microglia progenitors showed a distinct integrin surface profile and transmigrate along the extracellular matrix (ECM)-enriched pial surface into the CNS, pointing to a mesenchyme-to-CNS migration route. Loss of the integrin adaptor protein talin-1 in microglia progenitors led to a reduced CNS colonization, whereas macrophage progenitors in the surrounding mesenchyme remained unchanged. Overall, our data suggest that microglial progenitors enter the CNS parenchyma via talin-1-mediated migration from the surrounding mesenchyme through the ECM-enriched pial surface.
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000304507 650_7 $$2Other$$aembryonic microglia
000304507 650_7 $$2Other$$aimmune development
000304507 650_7 $$2Other$$aintegrins
000304507 650_7 $$2Other$$amacrophage progenitor migration
000304507 650_7 $$2Other$$amicroglia
000304507 650_7 $$2Other$$amicroglia development
000304507 650_7 $$2Other$$amicroglia progenitor recruitment
000304507 7001_ $$aOschwald, Alexander$$b1
000304507 7001_ $$aMerkt, Simon$$b2
000304507 7001_ $$aDinh, Thien-Ly Julia$$b3
000304507 7001_ $$aAndrieux, Geoffroy$$b4
000304507 7001_ $$aCrisand, Cylia$$b5
000304507 7001_ $$aBotterer, Hannah$$b6
000304507 7001_ $$aNent, Elisa$$b7
000304507 7001_ $$aPaterson, Neil$$b8
000304507 7001_ $$aHavermans, Monique$$b9
000304507 7001_ $$aSankowski, Roman$$b10
000304507 7001_ $$aSchilling, Oliver$$b11
000304507 7001_ $$0P:(DE-HGF)0$$aBoerries, Melanie$$b12
000304507 7001_ $$aAmann, Lukas$$b13
000304507 7001_ $$aGroß, Olaf$$b14
000304507 7001_ $$aSchlitzer, Andreas$$b15
000304507 7001_ $$aPrinz, Marco$$b16
000304507 7001_ $$aLämmermann, Tim$$b17
000304507 7001_ $$aKierdorf, Katrin$$b18
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