Journal Article

DKFZ-2025-01895

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface.

Petry, P. ; Oschwald, A. ; Merkt, S. ; Dinh, T. J. ; Andrieux, G. ; Crisand, C. ; Botterer, H. ; Nent, E. ; Paterson, N. ; Havermans, M. ; Sankowski, R. ; Schilling, O. ; Boerries, M.DKFZ* ; Amann, L. ; Groß, O. ; Schlitzer, A. ; Prinz, M. ; Lämmermann, T. ; Kierdorf, K.

2025
Cell Press Cambridge, Mass.

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Please use a persistent id in citations: doi:10.1016/j.devcel.2025.08.012

Abstract: Macrophage progenitors colonize their anatomical niches in the central nervous system (CNS) in distinct pre- and postnatal waves. Microglia progenitors originate from early erythromyeloid progenitors in the yolk sac and enter the murine CNS around embryonic day (E)9.5. While their developmental origin is well established, the molecular mechanisms guiding CNS colonization are not yet resolved. Using transcriptomic and proteomic approaches, we identified potential factors involved in this process. Microglia progenitors showed a distinct integrin surface profile and transmigrate along the extracellular matrix (ECM)-enriched pial surface into the CNS, pointing to a mesenchyme-to-CNS migration route. Loss of the integrin adaptor protein talin-1 in microglia progenitors led to a reduced CNS colonization, whereas macrophage progenitors in the surrounding mesenchyme remained unchanged. Overall, our data suggest that microglial progenitors enter the CNS parenchyma via talin-1-mediated migration from the surrounding mesenchyme through the ECM-enriched pial surface.

Keyword(s): embryonic microglia ; immune development ; integrins ; macrophage progenitor migration ; microglia ; microglia development ; microglia progenitor recruitment

Note: epub

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Freiburg (FR01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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