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@ARTICLE{Petry:304507,
      author       = {P. Petry and A. Oschwald and S. Merkt and T. J. Dinh and G.
                      Andrieux and C. Crisand and H. Botterer and E. Nent and N.
                      Paterson and M. Havermans and R. Sankowski and O. Schilling
                      and M. Boerries$^*$ and L. Amann and O. Groß and A.
                      Schlitzer and M. Prinz and T. Lämmermann and K. Kierdorf},
      title        = {{E}arly microglia progenitors colonize the embryonic {CNS}
                      via integrin-mediated migration from the pial surface.},
      journal      = {Developmental cell},
      volume       = {nn},
      issn         = {1534-5807},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-01895},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Macrophage progenitors colonize their anatomical niches in
                      the central nervous system (CNS) in distinct pre- and
                      postnatal waves. Microglia progenitors originate from early
                      erythromyeloid progenitors in the yolk sac and enter the
                      murine CNS around embryonic day (E)9.5. While their
                      developmental origin is well established, the molecular
                      mechanisms guiding CNS colonization are not yet resolved.
                      Using transcriptomic and proteomic approaches, we identified
                      potential factors involved in this process. Microglia
                      progenitors showed a distinct integrin surface profile and
                      transmigrate along the extracellular matrix (ECM)-enriched
                      pial surface into the CNS, pointing to a mesenchyme-to-CNS
                      migration route. Loss of the integrin adaptor protein
                      talin-1 in microglia progenitors led to a reduced CNS
                      colonization, whereas macrophage progenitors in the
                      surrounding mesenchyme remained unchanged. Overall, our data
                      suggest that microglial progenitors enter the CNS parenchyma
                      via talin-1-mediated migration from the surrounding
                      mesenchyme through the ECM-enriched pial surface.},
      keywords     = {embryonic microglia (Other) / immune development (Other) /
                      integrins (Other) / macrophage progenitor migration (Other)
                      / microglia (Other) / microglia development (Other) /
                      microglia progenitor recruitment (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40934928},
      doi          = {10.1016/j.devcel.2025.08.012},
      url          = {https://inrepo02.dkfz.de/record/304507},
}