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| Home > Publications database > Comparative analysis of target volume coverage and liver exposure in high-dose-rate interstitial brachytherapy and in silico MR LINAC-based stereotactic body radiotherapy plans for colorectal liver metastases |
| Home > Publications database > Comparative analysis of target volume coverage and liver exposure in high-dose-rate interstitial brachytherapy and in silico MR LINAC-based stereotactic body radiotherapy plans for colorectal liver metastases |
| Journal Article | DKFZ-2025-01930 |
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2025
Elsevier
Amsterdam
Abstract: Background: This study compared the plan quality and dosimetric parameters of single-fraction (SF) MR-LINAC (MRL)-based stereotactic body radiotherapy (SBRT) with delivered high-dose-rate interstitial brachytherapy (HDR-iBT) for colorectal liver metastases (CRLM). Methods: Between August 2017 and March 2019, 26 patients with a total of 45 CRLM were treated in 28 sessions using HDR-iBT with 1 x 25 Gy and were retrospectively included in this study. For each patient, an in silico MRLbased SBRT plan was generated using the corresponding iBT CT dataset. In the iBT plans, a single fraction of 25 Gy was prescribed to the periphery of the gross tumor volumes (GTVs), while in the SBRT plans, the same dose was prescribed to the 80% isodose line covering the planning target volumes (PTVs). We compared the dosimetric properties of the delivered HDR-iBT and MRL-based SBRT plans. Results: Median GTV was 3.83 cc (range: 0.13-92.58 cc) and median PTVSBRT was 15.47 cc (range: 2.68-164.17 cc). Both HDR-iBT and SBRT demonstrated excellent GTV coverage, with no statistically significant differences in GTV D98% (28.82 +/- 2.57 Gy vs. 28.92 +/- 0.88 Gy, p = 0.9). HDR-iBT achieved superior GTV D95% (31.62 +/- 3.20 Gy vs. 29.22 +/- 0.74 Gy, p < 0.01) and GTV D50% (64.71 +/- 12.78 Gy vs. 30.22 +/- 0.52 Gy, p < 0.01). Uninvolved liver dose metrics were higher in the SBRT plans compared to iBT, with a median relative difference in V5Gy of 5.29% (range: -13.69% to + 17.89%, p < 0.01) and a smaller relative difference in V10Gy of 1.5% (range: -7.74% to + 11.26%, p < 0.01). Conclusion: Our comparison indicates MRL-based SBRT to liver lesions is feasible, achieving adequate target volume coverage without clinically relevant violations of organ-at-risk (OAR) constraints.
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