guest ::
| Home > Publications database > Stereotactic body radiotherapy for spine and non-spine bone metastases in prostate carcinoma – a multicenter cohort analysis |
| Home > Publications database > Stereotactic body radiotherapy for spine and non-spine bone metastases in prostate carcinoma – a multicenter cohort analysis |
| Journal Article | DKFZ-2025-01961 |
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
2025
Elsevier
Amsterdam [u.a.]
Please use a persistent id in citations: doi:10.1016/j.jbo.2025.100710
Abstract: Background and purpose: Metastases-directed radiotherapy plays an increasing role in oligometastatic prostatecancers (OMPC). Here, we investigated the role of stereotactic body radiotherapy (SBRT) for spine and non-spinebone metastases (BoM) from prostate cancer in a large real-world multicenter cohort.Material and methods: This multicenter cohort analysis from five tertiary cancer centers included patient data ofspine and non-spine BoM irradiated between 2010 and 2024. Overall survival (OS), progression-free survival(PFS), local recurrence-free survival (LRFS), SBRT target volumes and doses, toxicity, and the role of additionalsystemic therapies were evaluated retrospectively.Results: 231 patients (341 BoM) with median follow-up time of 28.3 months were included. Most commonlocalization were spine (39.3 %), pelvic bone (31.7 %), and ribs (17.9 %). 1- and 5-year PFS for spine BoM were93.8 % (95 %CI:84.2–97.6 %) and 32.1 % (95 %CI:16.8–44.4 %) and for non-spine BoM 91.7 % (95 %CI:85.1–95.5 %) and 36.6 % (95 %CI:25.8–47.5 %), respectively. 1- and 5-year OS for spine BoM amounted to94.2 % (95 %CI:85.3–97.8 %) and 69.2 % (95 %CI:50.2–82.2 %) and for non-spine 100 % and 73.3 % (95 %CI:59.1–83.3 %). Older age (p < 0.005) and additional systemic therapies (p = 0.05) were associated with worseOS, older age and larger treatment volumes with worse PFS (p = 0.04). Toxicities were low, with fracture rates of0.3 % (acute) and 1.2 % (late).Conclusion: Bone SBRT for OMPC is an effective treatment with low toxicity and particularly low fracture rates forboth spine and non-spine BoM with no difference in outcome based on the localization. Prospective trials willhelp to identify the patients benefitting most from this approach and to establish standardized SBRT conceptsincorporating systemic treatments.
; 
; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
