%0 Journal Article
%A Deshpande, Divija
%A Velleman, Laura
%A Schmitz, Janna
%A Forster, Patrycja M
%A Schinke, Christian
%A Boulekou, Sotiria
%A Düsedau, Henning Peter
%A Krug, Susanne M
%A Mertens, Till
%A Gao, Xuemei
%A Figueiredo, Caio
%A Jarick, Katja J
%A Plum, Thomas
%A Sterczyk, Nele
%A Leclère, Pierre S
%A Helfrich, Sofia
%A Tappe-Theodor, Anke
%A Kotsch, Katja
%A Steffen, Johannes
%A Voehringer, David
%A Duerr, Claudia U
%A Hauser, Anja E
%A Artis, David
%A Pitzer, Claudia
%A Dunay, Ildiko R
%A Klose, Christoph S N
%T Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system.
%J Science immunology
%V 10
%N 111
%@ 2470-9468
%C Washington, DC
%I AAAS
%M DKFZ-2025-01972
%P eadp7092
%D 2025
%X The peripheral nervous system (PNS) is involved in nociception and gait. The contribution of PNS-resident immune cells to these functions is not fully understood. We identified group 2 innate lymphoid cells (ILC2s) as a distinct immune cell population resident in the PNS, with a unique gene profile facilitating neuron-ILC2 cross-talk. ILC2-deficient mice display PNS dysfunction (hypersensitivity and gait anomalies). These functional deficits are attributed to structural abnormalities in the sciatic nerves of ILC2-deficient mice. ILC2s communicate with dorsal root ganglion neurons via the interleukin-13 (IL-13) signaling pathway to maintain nerve structure and pain thresholds. Loss of the shared IL-4/IL-13 receptor (IL-4R/IL-13R) in neurons results in a phenotype similar to ILC2-deficient mice. Intrathecally administered IL-13 rescues hypersensitivity and gait defects in ILC2-deficient mice, which suggests that this signaling pathway may be therapeutically important. This work therefore identifies a function for ILC2s in regulating the nerve structural integrity and nociceptive functions of the PNS.
%K Animals
%K Mice
%K Immunity, Innate
%K Mice, Knockout
%K Lymphocytes: immunology
%K Gait: immunology
%K Peripheral Nervous System: immunology
%K Mice, Inbred C57BL
%K Interleukin-13: immunology
%K Nociception
%K Male
%K Ganglia, Spinal: immunology
%K Signal Transduction
%K Interleukin-13 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41004566
%R 10.1126/sciimmunol.adp7092
%U https://inrepo02.dkfz.de/record/304981