Journal Article

DKFZ-2025-01972

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system.

Deshpande, D. ; Velleman, L. ; Schmitz, J. ; Forster, P. M. ; Schinke, C. ; Boulekou, S. ; Düsedau, H. P. ; Krug, S. M. ; Mertens, T. ; Gao, X. ; Figueiredo, C. ; Jarick, K. J. ; Plum, T.DKFZ* ; Sterczyk, N. ; Leclère, P. S. ; Helfrich, S. ; Tappe-Theodor, A. ; Kotsch, K. ; Steffen, J. ; Voehringer, D. ; Duerr, C. U. ; Hauser, A. E. ; Artis, D. ; Pitzer, C. ; Dunay, I. R. ; Klose, C. S. N.

2025
AAAS Washington, DC

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Please use a persistent id in citations: doi:10.1126/sciimmunol.adp7092

Abstract: The peripheral nervous system (PNS) is involved in nociception and gait. The contribution of PNS-resident immune cells to these functions is not fully understood. We identified group 2 innate lymphoid cells (ILC2s) as a distinct immune cell population resident in the PNS, with a unique gene profile facilitating neuron-ILC2 cross-talk. ILC2-deficient mice display PNS dysfunction (hypersensitivity and gait anomalies). These functional deficits are attributed to structural abnormalities in the sciatic nerves of ILC2-deficient mice. ILC2s communicate with dorsal root ganglion neurons via the interleukin-13 (IL-13) signaling pathway to maintain nerve structure and pain thresholds. Loss of the shared IL-4/IL-13 receptor (IL-4R/IL-13R) in neurons results in a phenotype similar to ILC2-deficient mice. Intrathecally administered IL-13 rescues hypersensitivity and gait defects in ILC2-deficient mice, which suggests that this signaling pathway may be therapeutically important. This work therefore identifies a function for ILC2s in regulating the nerve structural integrity and nociceptive functions of the PNS.

Keyword(s): Animals (MeSH) ; Mice (MeSH) ; Immunity, Innate (MeSH) ; Mice, Knockout (MeSH) ; Lymphocytes: immunology (MeSH) ; Gait: immunology (MeSH) ; Peripheral Nervous System: immunology (MeSH) ; Mice, Inbred C57BL (MeSH) ; Interleukin-13: immunology (MeSH) ; Nociception (MeSH) ; Male (MeSH) ; Ganglia, Spinal: immunology (MeSH) ; Signal Transduction (MeSH) ; Interleukin-13

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Contributing Institute(s):

1. Zelluläre Immunologie (D110)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF >= 20 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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