TY  - JOUR
AU  - Deshpande, Divija
AU  - Velleman, Laura
AU  - Schmitz, Janna
AU  - Forster, Patrycja M
AU  - Schinke, Christian
AU  - Boulekou, Sotiria
AU  - Düsedau, Henning Peter
AU  - Krug, Susanne M
AU  - Mertens, Till
AU  - Gao, Xuemei
AU  - Figueiredo, Caio
AU  - Jarick, Katja J
AU  - Plum, Thomas
AU  - Sterczyk, Nele
AU  - Leclère, Pierre S
AU  - Helfrich, Sofia
AU  - Tappe-Theodor, Anke
AU  - Kotsch, Katja
AU  - Steffen, Johannes
AU  - Voehringer, David
AU  - Duerr, Claudia U
AU  - Hauser, Anja E
AU  - Artis, David
AU  - Pitzer, Claudia
AU  - Dunay, Ildiko R
AU  - Klose, Christoph S N
TI  - Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system.
JO  - Science immunology
VL  - 10
IS  - 111
SN  - 2470-9468
CY  - Washington, DC
PB  - AAAS
M1  - DKFZ-2025-01972
SP  - eadp7092
PY  - 2025
AB  - The peripheral nervous system (PNS) is involved in nociception and gait. The contribution of PNS-resident immune cells to these functions is not fully understood. We identified group 2 innate lymphoid cells (ILC2s) as a distinct immune cell population resident in the PNS, with a unique gene profile facilitating neuron-ILC2 cross-talk. ILC2-deficient mice display PNS dysfunction (hypersensitivity and gait anomalies). These functional deficits are attributed to structural abnormalities in the sciatic nerves of ILC2-deficient mice. ILC2s communicate with dorsal root ganglion neurons via the interleukin-13 (IL-13) signaling pathway to maintain nerve structure and pain thresholds. Loss of the shared IL-4/IL-13 receptor (IL-4R/IL-13R) in neurons results in a phenotype similar to ILC2-deficient mice. Intrathecally administered IL-13 rescues hypersensitivity and gait defects in ILC2-deficient mice, which suggests that this signaling pathway may be therapeutically important. This work therefore identifies a function for ILC2s in regulating the nerve structural integrity and nociceptive functions of the PNS.
KW  - Animals
KW  - Mice
KW  - Immunity, Innate
KW  - Mice, Knockout
KW  - Lymphocytes: immunology
KW  - Gait: immunology
KW  - Peripheral Nervous System: immunology
KW  - Mice, Inbred C57BL
KW  - Interleukin-13: immunology
KW  - Nociception
KW  - Male
KW  - Ganglia, Spinal: immunology
KW  - Signal Transduction
KW  - Interleukin-13 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41004566
DO  - DOI:10.1126/sciimmunol.adp7092
UR  - https://inrepo02.dkfz.de/record/304981
ER  -