Journal Article

DKFZ-2025-02009

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A Specific Methylation Class Identifies BAP1-Deficient Meningiomas, Including Meningeal Tumours With Poorly Differentiated Nonrhabdoid Histology.

Drabent, P. ; Touat, M. ; Benusiglio, P. R. ; Euskirchen, P.DKFZ* ; Coulet, F. ; Oumoussa, B. M. ; de la Fouchardière, A. ; de Montpreville, V. T. ; Jacob, J. ; Bernardeschi, D. ; Laurent-Puig, P. ; Sanson, M. ; Kalamarides, M. ; Bielle, F.

2025
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/nan.70042

Abstract: BAP1-deficient meningiomas have a preferential infratentorial or spinal localization and may present with an undifferentiated histology of small or epithelioid cells rather than the meningothelial, rhabdoid or papillary variants. Frequent expression of cytokeratins may be misleading for a metastatic carcinoma but loss of BAP1 immunostaining in tumor cells and a specific methylation class enable the diagnosis. The clinical impact of the histomolecular diagnosis of BAP1-deficient meningioma is the high risk of relapse and a possible underlying BAP1 tumour predisposition syndrome.

Keyword(s): Humans (MeSH) ; Meningioma: pathology (MeSH) ; Meningioma: genetics (MeSH) ; Meningioma: diagnosis (MeSH) ; Meningioma: metabolism (MeSH) ; Ubiquitin Thiolesterase: deficiency (MeSH) ; Ubiquitin Thiolesterase: genetics (MeSH) ; Meningeal Neoplasms: pathology (MeSH) ; Meningeal Neoplasms: genetics (MeSH) ; Meningeal Neoplasms: diagnosis (MeSH) ; Meningeal Neoplasms: metabolism (MeSH) ; Tumor Suppressor Proteins: deficiency (MeSH) ; Tumor Suppressor Proteins: genetics (MeSH) ; DNA Methylation (MeSH) ; Female (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Adult (MeSH) ; BAP1 ; homologous repair deficiency ; infratentorial ; meningeal tumour ; meningioma ; methylome ; papillary ; rhabdoid ; spine ; tumour predisposition syndrome ; BAP1 protein, human ; Ubiquitin Thiolesterase ; Tumor Suppressor Proteins

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Contributing Institute(s):

1. DKTK Koordinierungsstelle Berlin (BE01)

Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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