%0 Journal Article
%A Puri, Tanuj
%A Rancati, Tiziana
%A Seibold, Petra
%A Webb, Adam
%A Osorio, Eliana Vasquez
%A Azria, David
%A Farcy-Jacquet, Marie-Pierre
%A Chang-Claude, Jenny
%A Dunning, Alison
%A Lambrecht, Maarten
%A Avuzzi, Barbara
%A de Ruysscher, Dirk
%A Sperk, Elena
%A Vega, Ana
%A Veldeman, Liv
%A Rosenstein, Barry
%A Kerns, Sarah
%A Talbot, Christopher
%A McWilliam, Alan
%A Hoskin, Peter
%A Choudhury, Ananya
%A West, Catharine
%A van Herk, Marcel
%T Sensitivity analysis of dose-response model parameters for the bladder in prostate cancer radiotherapy.
%J Physica medica
%V 139
%@ 1120-1797
%C Amsterdam
%I Elsevier
%M DKFZ-2025-02087
%P 105178
%D 2025
%X This study evaluates how model parameter values affect dose-response maps (DRMs) in identifying high-risk bladder subregions associated with late urinary toxicities in prostate cancer patients post-radiotherapy.Data from 1808 patients were analyzed for five late bladder toxicities. Baseline scores were subtracted from maximum toxicity at 12 and 24 months and dichotomized into grades ≥ 1 and ≥ 2. Bladders were segmented on computed tomography scans, and dose-surface maps (DSMs) were created on 91 × 90 voxel grids using spherical and cylindrical coordinates. Voxel doses were converted to equivalent dose in 2 Gy fractions (EQD2, α/β 1-3 Gy). Welch's t and Mann-Whitney U equations were applied at each voxel location. Multiple comparisons were corrected via permutation testing (10-10000 iterations), and statistically significant voxels were identified using the 90th and 95th percentiles of Tmax/Umax. Sensitivity of parameters was assessed by varying one parameter at a time, with changes > 400 voxels (∼5
%K Bladder (Other)
%K IBDM (Other)
%K Image-based data mining (Other)
%K Imaging biomarker (Other)
%K Multicenter clinical trial (Other)
%K OAR (Other)
%K Organ-at-risk (Other)
%K Prediction model (Other)
%K Predictive modeling (Other)
%K Prostate cancer (Other)
%K Radiotherapy (Other)
%K Standardization (Other)
%K Toxicity (Other)
%K VBA (Other)
%K Voxel-based dose–response analysis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41072101
%R 10.1016/j.ejmp.2025.105178
%U https://inrepo02.dkfz.de/record/305343