TY  - JOUR
AU  - Puri, Tanuj
AU  - Rancati, Tiziana
AU  - Seibold, Petra
AU  - Webb, Adam
AU  - Osorio, Eliana Vasquez
AU  - Azria, David
AU  - Farcy-Jacquet, Marie-Pierre
AU  - Chang-Claude, Jenny
AU  - Dunning, Alison
AU  - Lambrecht, Maarten
AU  - Avuzzi, Barbara
AU  - de Ruysscher, Dirk
AU  - Sperk, Elena
AU  - Vega, Ana
AU  - Veldeman, Liv
AU  - Rosenstein, Barry
AU  - Kerns, Sarah
AU  - Talbot, Christopher
AU  - McWilliam, Alan
AU  - Hoskin, Peter
AU  - Choudhury, Ananya
AU  - West, Catharine
AU  - van Herk, Marcel
TI  - Sensitivity analysis of dose-response model parameters for the bladder in prostate cancer radiotherapy.
JO  - Physica medica
VL  - 139
SN  - 1120-1797
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2025-02087
SP  - 105178
PY  - 2025
AB  - This study evaluates how model parameter values affect dose-response maps (DRMs) in identifying high-risk bladder subregions associated with late urinary toxicities in prostate cancer patients post-radiotherapy.Data from 1808 patients were analyzed for five late bladder toxicities. Baseline scores were subtracted from maximum toxicity at 12 and 24 months and dichotomized into grades ≥ 1 and ≥ 2. Bladders were segmented on computed tomography scans, and dose-surface maps (DSMs) were created on 91 × 90 voxel grids using spherical and cylindrical coordinates. Voxel doses were converted to equivalent dose in 2 Gy fractions (EQD2, α/β 1-3 Gy). Welch's t and Mann-Whitney U equations were applied at each voxel location. Multiple comparisons were corrected via permutation testing (10-10000 iterations), and statistically significant voxels were identified using the 90th and 95th percentiles of Tmax/Umax. Sensitivity of parameters was assessed by varying one parameter at a time, with changes > 400 voxels (∼5
KW  - Bladder (Other)
KW  - IBDM (Other)
KW  - Image-based data mining (Other)
KW  - Imaging biomarker (Other)
KW  - Multicenter clinical trial (Other)
KW  - OAR (Other)
KW  - Organ-at-risk (Other)
KW  - Prediction model (Other)
KW  - Predictive modeling (Other)
KW  - Prostate cancer (Other)
KW  - Radiotherapy (Other)
KW  - Standardization (Other)
KW  - Toxicity (Other)
KW  - VBA (Other)
KW  - Voxel-based dose–response analysis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41072101
DO  - DOI:10.1016/j.ejmp.2025.105178
UR  - https://inrepo02.dkfz.de/record/305343
ER  -