Journal Article

DKFZ-2025-02091

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Epstein-Barr Virus Antibody Response Patterns in Endemic and Non-Endemic Cases of Nasopharyngeal Carcinoma.

Argirion, I. ; Babi, A. (First author)DKFZ* ; Simon, J.DKFZ* ; Waterboer, T.DKFZ* ; Hsu, W.-L. ; Chen, C.-J. ; Yu, K. J. ; Pring, M. ; Hurley, K. ; Hildesheim, A. ; Liu, Z.

2026
Oxford Univ. Press Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1093/infdis/jiaf526

Abstract: Epstein-Barr virus (EBV) causes most nasopharyngeal carcinoma (NPC), a malignancy endemic in certain regions, presenting with non-specific symptoms and lacking a robust minimally-invasive biomarker. To assess previously developed multiplex Luminex assay EBV antibody signatures in non-endemic population, we analyzed and compared 98 NPC sera and 142 matched controls from the non-endemic Head and Neck 5000 clinical cohort to an endemic Taiwan case-control cohort. All models-except the two-antibody IgA panel-performed similarly, achieving 90-99 % accuracy in identifying EBV-positive NPC. Our results showed that EBV antibody panels can accurately define EBV-positive NPC regardless of endemicity.Keywords: Epstein-Barr virus, nasopharyngeal carcinoma, humoral immune response, antibodies, protein array, endemicity.

Note: #EA:D320# /2026 Feb 18;233(2):e404-e408

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Contributing Institute(s):

1. Infektionen und Krebs-Epidemiologie (D320)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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