000305362 001__ 305362
000305362 005__ 20251027132945.0
000305362 0247_ $$2doi$$a10.1088/1361-6560/ae128f
000305362 0247_ $$2pmid$$apmid:41082905
000305362 0247_ $$2ISSN$$a0031-9155
000305362 0247_ $$2ISSN$$a1361-6560
000305362 037__ $$aDKFZ-2025-02106
000305362 041__ $$aEnglish
000305362 082__ $$a530
000305362 1001_ $$00000-0001-9534-9034$$aJensen, Mads Lykke$$b0
000305362 245__ $$aAchieving high-resolution spatial mapping of dose and linear energy transfer in ion-beam therapy.
000305362 260__ $$aBristol$$bIOP Publ.$$c2025
000305362 3367_ $$2DRIVER$$aarticle
000305362 3367_ $$2DataCite$$aOutput Types/Journal article
000305362 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1761568142_3448744
000305362 3367_ $$2BibTeX$$aARTICLE
000305362 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000305362 3367_ $$00$$2EndNote$$aJournal Article
000305362 500__ $$aMed. Biol. 70 215008
000305362 520__ $$aObjective:We present a novel detector system capable of simultaneously obtaining two-dimensional (2D) dose and linear energy transfer (LET) maps from Al2O3films of sizes up to 190x190 mm2using optically stimulated luminescence (OSL).&#xD;Approach:The system is based on the OSL from doped Al2O3films measured using pulsed stimulation and time-resolved OSL detection. The system was calibrated in proton,4He-, and12C-ion beams. The minimal detectable dose, response homogeneity, pixel cross-stimulation, and precision were also investigated. To demonstrate the system's performance, 2D maps of dose and LET of a proton Bragg curve were measured.&#xD;Main results:The system was demonstrated to be capable of obtaining absorbed dose and LET 2D maps with a spatial resolution set to 1.0x1.0 mm2. The system was calibrated over a clinically relevant range of LET values and characterized through assessment of minimal detectable dose (<25 mGy), readout protocols, response homogeneity, precision, and relative detector efficiency. Dose and LET were found to be measurable with precisions of 3.2% and 10%, respectively.&#xD;Significance:To our knowledge, this is the first passive detector system capable of measuring LET and dose simultaneously in 2D with a 1.0 mm2spatial resolution and no prior dose knowledge. Such properties are required to experimentally validate simulated dose and LET distributions in ion-beam therapy, paving the way for sub-mm mapping of radiation-induced relative biological effectiveness.
000305362 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000305362 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000305362 650_7 $$2Other$$a2D mapping
000305362 650_7 $$2Other$$aDosimetry
000305362 650_7 $$2Other$$aIon-beam Therapy
000305362 650_7 $$2Other$$aLET
000305362 650_7 $$2Other$$aOSL
000305362 650_7 $$2Other$$aProton therapy
000305362 650_7 $$2Other$$aRadiotherapy
000305362 7001_ $$aTogno, Michele$$b1
000305362 7001_ $$aMuñoz, Iván Domingo$$b2
000305362 7001_ $$00000-0002-4695-0816$$aBrons, Stephan$$b3
000305362 7001_ $$00000-0002-6056-9747$$aJaekel, Oliver$$b4
000305362 7001_ $$00000-0002-4615-6698$$aYukihara, Eduardo G$$b5
000305362 7001_ $$00000-0002-6894-381X$$aChristensen, Jeppe Brage$$b6
000305362 773__ $$0PERI:(DE-600)1473501-5$$a10.1088/1361-6560/ae128f$$n21$$p215008$$tPhysics in medicine and biology$$v70$$x0031-9155$$y2025
000305362 909CO $$ooai:inrepo02.dkfz.de:305362$$pVDB
000305362 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-6056-9747$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000305362 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000305362 9141_ $$y2025
000305362 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2024-12-27$$wger
000305362 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPHYS MED BIOL : 2022$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-27
000305362 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-27
000305362 9201_ $$0I:(DE-He78)E040-20160331$$kE040$$lE040 Med. Physik in der Strahlentherapie$$x0
000305362 980__ $$ajournal
000305362 980__ $$aVDB
000305362 980__ $$aI:(DE-He78)E040-20160331
000305362 980__ $$aUNRESTRICTED