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| Home > Publications database > Achieving high-resolution spatial mapping of dose and linear energy transfer in ion-beam therapy. |
| Journal Article | DKFZ-2025-02106 |
; ; ; ; ; ;
2025
IOP Publ.
Bristol
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Please use a persistent id in citations: doi:10.1088/1361-6560/ae128f
Abstract: Objective:We present a novel detector system capable of simultaneously obtaining two-dimensional (2D) dose and linear energy transfer (LET) maps from Al2O3films of sizes up to 190x190 mm2using optically stimulated luminescence (OSL).
Approach:The system is based on the OSL from doped Al2O3films measured using pulsed stimulation and time-resolved OSL detection. The system was calibrated in proton,4He-, and12C-ion beams. The minimal detectable dose, response homogeneity, pixel cross-stimulation, and precision were also investigated. To demonstrate the system's performance, 2D maps of dose and LET of a proton Bragg curve were measured.
Main results:The system was demonstrated to be capable of obtaining absorbed dose and LET 2D maps with a spatial resolution set to 1.0x1.0 mm2. The system was calibrated over a clinically relevant range of LET values and characterized through assessment of minimal detectable dose (<25 mGy), readout protocols, response homogeneity, precision, and relative detector efficiency. Dose and LET were found to be measurable with precisions of 3.2% and 10%, respectively.
Significance:To our knowledge, this is the first passive detector system capable of measuring LET and dose simultaneously in 2D with a 1.0 mm2spatial resolution and no prior dose knowledge. Such properties are required to experimentally validate simulated dose and LET distributions in ion-beam therapy, paving the way for sub-mm mapping of radiation-induced relative biological effectiveness.
Keyword(s): 2D mapping ; Dosimetry ; Ion-beam Therapy ; LET ; OSL ; Proton therapy ; Radiotherapy
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