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@ARTICLE{Jensen:305362,
      author       = {M. L. Jensen and M. Togno and I. D. Muñoz and S. Brons and
                      O. Jaekel$^*$ and E. G. Yukihara and J. B. Christensen},
      title        = {{A}chieving high-resolution spatial mapping of dose and
                      linear energy transfer in ion-beam therapy.},
      journal      = {Physics in medicine and biology},
      volume       = {70},
      number       = {21},
      issn         = {0031-9155},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2025-02106},
      pages        = {215008},
      year         = {2025},
      note         = {Med. Biol. 70 215008},
      abstract     = {Objective:We present a novel detector system capable of
                      simultaneously obtaining two-dimensional (2D) dose and
                      linear energy transfer (LET) maps from Al2O3films of sizes
                      up to 190x190 mm2using optically stimulated luminescence
                      $(OSL).\
Approach:The$ system is based on the OSL from
                      doped Al2O3films measured using pulsed stimulation and
                      time-resolved OSL detection. The system was calibrated in
                      proton,4He-, and12C-ion beams. The minimal detectable dose,
                      response homogeneity, pixel cross-stimulation, and precision
                      were also investigated. To demonstrate the system's
                      performance, 2D maps of dose and LET of a proton Bragg curve
                      were $measured.\
Main$ results:The system was
                      demonstrated to be capable of obtaining absorbed dose and
                      LET 2D maps with a spatial resolution set to 1.0x1.0 mm2.
                      The system was calibrated over a clinically relevant range
                      of LET values and characterized through assessment of
                      minimal detectable dose (<25 mGy), readout protocols,
                      response homogeneity, precision, and relative detector
                      efficiency. Dose and LET were found to be measurable with
                      precisions of $3.2\%$ and $10\%,$
                      $respectively.\&#xD;Significance:To$ our knowledge, this is
                      the first passive detector system capable of measuring LET
                      and dose simultaneously in 2D with a 1.0 mm2spatial
                      resolution and no prior dose knowledge. Such properties are
                      required to experimentally validate simulated dose and LET
                      distributions in ion-beam therapy, paving the way for sub-mm
                      mapping of radiation-induced relative biological
                      effectiveness.},
      keywords     = {2D mapping (Other) / Dosimetry (Other) / Ion-beam Therapy
                      (Other) / LET (Other) / OSL (Other) / Proton therapy (Other)
                      / Radiotherapy (Other)},
      cin          = {E040},
      ddc          = {530},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41082905},
      doi          = {10.1088/1361-6560/ae128f},
      url          = {https://inrepo02.dkfz.de/record/305362},
}