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001     305362
005     20251027132945.0
024 7 _ |a 10.1088/1361-6560/ae128f
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024 7 _ |a 1361-6560
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037 _ _ |a DKFZ-2025-02106
041 _ _ |a English
082 _ _ |a 530
100 1 _ |a Jensen, Mads Lykke
|0 0000-0001-9534-9034
|b 0
245 _ _ |a Achieving high-resolution spatial mapping of dose and linear energy transfer in ion-beam therapy.
260 _ _ |a Bristol
|c 2025
|b IOP Publ.
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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500 _ _ |a Med. Biol. 70 215008
520 _ _ |a Objective:We present a novel detector system capable of simultaneously obtaining two-dimensional (2D) dose and linear energy transfer (LET) maps from Al2O3films of sizes up to 190x190 mm2using optically stimulated luminescence (OSL). Approach:The system is based on the OSL from doped Al2O3films measured using pulsed stimulation and time-resolved OSL detection. The system was calibrated in proton,4He-, and12C-ion beams. The minimal detectable dose, response homogeneity, pixel cross-stimulation, and precision were also investigated. To demonstrate the system's performance, 2D maps of dose and LET of a proton Bragg curve were measured. Main results:The system was demonstrated to be capable of obtaining absorbed dose and LET 2D maps with a spatial resolution set to 1.0x1.0 mm2. The system was calibrated over a clinically relevant range of LET values and characterized through assessment of minimal detectable dose (<25 mGy), readout protocols, response homogeneity, precision, and relative detector efficiency. Dose and LET were found to be measurable with precisions of 3.2% and 10%, respectively. Significance:To our knowledge, this is the first passive detector system capable of measuring LET and dose simultaneously in 2D with a 1.0 mm2spatial resolution and no prior dose knowledge. Such properties are required to experimentally validate simulated dose and LET distributions in ion-beam therapy, paving the way for sub-mm mapping of radiation-induced relative biological effectiveness.
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650 _ 7 |a 2D mapping
|2 Other
650 _ 7 |a Dosimetry
|2 Other
650 _ 7 |a Ion-beam Therapy
|2 Other
650 _ 7 |a LET
|2 Other
650 _ 7 |a OSL
|2 Other
650 _ 7 |a Proton therapy
|2 Other
650 _ 7 |a Radiotherapy
|2 Other
700 1 _ |a Togno, Michele
|b 1
700 1 _ |a Muñoz, Iván Domingo
|b 2
700 1 _ |a Brons, Stephan
|0 0000-0002-4695-0816
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700 1 _ |a Jaekel, Oliver
|0 0000-0002-6056-9747
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700 1 _ |a Yukihara, Eduardo G
|0 0000-0002-4615-6698
|b 5
700 1 _ |a Christensen, Jeppe Brage
|0 0000-0002-6894-381X
|b 6
773 _ _ |a 10.1088/1361-6560/ae128f
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|y 2025
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910 1 _ |a Deutsches Krebsforschungszentrum
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