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000306541 1001_ $$00000-0001-9835-3741$$aBrinkert, Pia$$b0
000306541 245__ $$aThe actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses.
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000306541 520__ $$aEndocytosis is a fundamental cellular process facilitated by diverse mechanisms. Remarkably, several distinct clathrin-independent endocytic processes have been identified and characterized following virus uptake into cells. For some, however, mechanistic execution and biological function remain largely unclear. This includes an endocytic process exploited by human papillomavirus type 16 (HPV16). Using HPV16, we examine how vesicles are formed by combining systematic cellular perturbations with electron and video microscopy. Cargo uptake occurs by uncoated, inward-budding pits. Mechanistically, vesicle scission is facilitated by actin polymerization controlled through the actin nucleation-promoting factor WASH. While WASH typically functions in conjunction with the retromer complex on endosomes during retrograde trafficking, endocytic vesicle formation is largely independent of retromer itself and the heterodimeric membrane-bending SNX-BAR retromer adaptor, thereby uncovering a role of WASH in endocytosis in addition to its canonical role in intracellular membrane trafficking.
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000306541 650_7 $$2Other$$aActin
000306541 650_7 $$2Other$$aEndocytosis
000306541 650_7 $$2Other$$aNucleation Promoting Factor
000306541 650_7 $$2Other$$aVirus Entry
000306541 650_7 $$2Other$$aWASH
000306541 650_7 $$2NLM Chemicals$$aClathrin
000306541 650_7 $$2NLM Chemicals$$aActins
000306541 650_7 $$2NLM Chemicals$$aMicrofilament Proteins
000306541 650_7 $$2NLM Chemicals$$aWASH protein, human
000306541 650_2 $$2MeSH$$aEndocytosis
000306541 650_2 $$2MeSH$$aHumans
000306541 650_2 $$2MeSH$$aClathrin: metabolism
000306541 650_2 $$2MeSH$$aActins: metabolism
000306541 650_2 $$2MeSH$$aHuman papillomavirus 16: physiology
000306541 650_2 $$2MeSH$$aMicrofilament Proteins: metabolism
000306541 650_2 $$2MeSH$$aMicrofilament Proteins: genetics
000306541 650_2 $$2MeSH$$aEndosomes: metabolism
000306541 650_2 $$2MeSH$$aVirus Internalization
000306541 650_2 $$2MeSH$$aHeLa Cells
000306541 650_2 $$2MeSH$$aPapillomavirus Infections: virology
000306541 650_2 $$2MeSH$$aPapillomavirus Infections: metabolism
000306541 650_2 $$2MeSH$$aHuman Papillomavirus Viruses
000306541 7001_ $$aKrebs, Lena$$b1
000306541 7001_ $$00000-0002-3726-7871$$aSamperio Ventayol, Pilar$$b2
000306541 7001_ $$00000-0002-6228-4657$$aGreune, Lilo$$b3
000306541 7001_ $$aBannach, Carina$$b4
000306541 7001_ $$00009-0004-9611-5925$$aAmakiri, Cynthia$$b5
000306541 7001_ $$aBucher, Delia$$b6
000306541 7001_ $$aKollasser, Jana$$b7
000306541 7001_ $$00000-0001-8177-3280$$aDersch, Petra$$b8
000306541 7001_ $$0P:(DE-He78)4658b59d5b4e54b919fc63ab1213c78f$$aBoulant, Steeve$$b9
000306541 7001_ $$aStradal, Theresia E B$$b10
000306541 7001_ $$00000-0002-6735-583X$$aSchelhaas, Mario$$b11
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