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@ARTICLE{Brinkert:306541,
      author       = {P. Brinkert and L. Krebs and P. Samperio Ventayol and L.
                      Greune and C. Bannach and C. Amakiri and D. Bucher and J.
                      Kollasser and P. Dersch and S. Boulant$^*$ and T. E. B.
                      Stradal and M. Schelhaas},
      title        = {{T}he actin nucleation promoting factor {WASH} facilitates
                      clathrin-independent endocytosis of human papillomaviruses.},
      journal      = {EMBO reports},
      volume       = {26},
      number       = {22},
      issn         = {1469-221X},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2025-02606},
      pages        = {5533 - 5566},
      year         = {2025},
      abstract     = {Endocytosis is a fundamental cellular process facilitated
                      by diverse mechanisms. Remarkably, several distinct
                      clathrin-independent endocytic processes have been
                      identified and characterized following virus uptake into
                      cells. For some, however, mechanistic execution and
                      biological function remain largely unclear. This includes an
                      endocytic process exploited by human papillomavirus type 16
                      (HPV16). Using HPV16, we examine how vesicles are formed by
                      combining systematic cellular perturbations with electron
                      and video microscopy. Cargo uptake occurs by uncoated,
                      inward-budding pits. Mechanistically, vesicle scission is
                      facilitated by actin polymerization controlled through the
                      actin nucleation-promoting factor WASH. While WASH typically
                      functions in conjunction with the retromer complex on
                      endosomes during retrograde trafficking, endocytic vesicle
                      formation is largely independent of retromer itself and the
                      heterodimeric membrane-bending SNX-BAR retromer adaptor,
                      thereby uncovering a role of WASH in endocytosis in addition
                      to its canonical role in intracellular membrane
                      trafficking.},
      keywords     = {Endocytosis / Humans / Clathrin: metabolism / Actins:
                      metabolism / Human papillomavirus 16: physiology /
                      Microfilament Proteins: metabolism / Microfilament Proteins:
                      genetics / Endosomes: metabolism / Virus Internalization /
                      HeLa Cells / Papillomavirus Infections: virology /
                      Papillomavirus Infections: metabolism / Human Papillomavirus
                      Viruses / Actin (Other) / Endocytosis (Other) / Nucleation
                      Promoting Factor (Other) / Virus Entry (Other) / WASH
                      (Other) / Clathrin (NLM Chemicals) / Actins (NLM Chemicals)
                      / Microfilament Proteins (NLM Chemicals) / WASH protein,
                      human (NLM Chemicals)},
      cin          = {F140},
      ddc          = {570},
      cid          = {I:(DE-He78)F140-20160331},
      pnm          = {319H - Addenda (POF4-319H)},
      pid          = {G:(DE-HGF)POF4-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41073792},
      pmc          = {pmc:PMC12635285},
      doi          = {10.1038/s44319-025-00594-3},
      url          = {https://inrepo02.dkfz.de/record/306541},
}