Home > Publications database > The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses. > print

001     306541
005     20251126115911.0
024 7 _ |a 10.1038/s44319-025-00594-3
|2 doi
024 7 _ |a pmid:41073792
|2 pmid
024 7 _ |a pmc:PMC12635285
|2 pmc
024 7 _ |a 1469-221X
|2 ISSN
024 7 _ |a 1469-3178
|2 ISSN
037 _ _ |a DKFZ-2025-02606
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Brinkert, Pia
|0 0000-0001-9835-3741
|b 0
245 _ _ |a The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses.
260 _ _ |a [London]
|c 2025
|b Nature Publishing Group UK
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1764076143_3576549
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Endocytosis is a fundamental cellular process facilitated by diverse mechanisms. Remarkably, several distinct clathrin-independent endocytic processes have been identified and characterized following virus uptake into cells. For some, however, mechanistic execution and biological function remain largely unclear. This includes an endocytic process exploited by human papillomavirus type 16 (HPV16). Using HPV16, we examine how vesicles are formed by combining systematic cellular perturbations with electron and video microscopy. Cargo uptake occurs by uncoated, inward-budding pits. Mechanistically, vesicle scission is facilitated by actin polymerization controlled through the actin nucleation-promoting factor WASH. While WASH typically functions in conjunction with the retromer complex on endosomes during retrograde trafficking, endocytic vesicle formation is largely independent of retromer itself and the heterodimeric membrane-bending SNX-BAR retromer adaptor, thereby uncovering a role of WASH in endocytosis in addition to its canonical role in intracellular membrane trafficking.
536 _ _ |a 319H - Addenda (POF4-319H)
|0 G:(DE-HGF)POF4-319H
|c POF4-319H
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
650 _ 7 |a Actin
|2 Other
650 _ 7 |a Endocytosis
|2 Other
650 _ 7 |a Nucleation Promoting Factor
|2 Other
650 _ 7 |a Virus Entry
|2 Other
650 _ 7 |a WASH
|2 Other
650 _ 7 |a Clathrin
|2 NLM Chemicals
650 _ 7 |a Actins
|2 NLM Chemicals
650 _ 7 |a Microfilament Proteins
|2 NLM Chemicals
650 _ 7 |a WASH protein, human
|2 NLM Chemicals
650 _ 2 |a Endocytosis
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Clathrin: metabolism
|2 MeSH
650 _ 2 |a Actins: metabolism
|2 MeSH
650 _ 2 |a Human papillomavirus 16: physiology
|2 MeSH
650 _ 2 |a Microfilament Proteins: metabolism
|2 MeSH
650 _ 2 |a Microfilament Proteins: genetics
|2 MeSH
650 _ 2 |a Endosomes: metabolism
|2 MeSH
650 _ 2 |a Virus Internalization
|2 MeSH
650 _ 2 |a HeLa Cells
|2 MeSH
650 _ 2 |a Papillomavirus Infections: virology
|2 MeSH
650 _ 2 |a Papillomavirus Infections: metabolism
|2 MeSH
650 _ 2 |a Human Papillomavirus Viruses
|2 MeSH
700 1 _ |a Krebs, Lena
|b 1
700 1 _ |a Samperio Ventayol, Pilar
|0 0000-0002-3726-7871
|b 2
700 1 _ |a Greune, Lilo
|0 0000-0002-6228-4657
|b 3
700 1 _ |a Bannach, Carina
|b 4
700 1 _ |a Amakiri, Cynthia
|0 0009-0004-9611-5925
|b 5
700 1 _ |a Bucher, Delia
|b 6
700 1 _ |a Kollasser, Jana
|b 7
700 1 _ |a Dersch, Petra
|0 0000-0001-8177-3280
|b 8
700 1 _ |a Boulant, Steeve
|0 P:(DE-He78)4658b59d5b4e54b919fc63ab1213c78f
|b 9
700 1 _ |a Stradal, Theresia E B
|b 10
700 1 _ |a Schelhaas, Mario
|0 0000-0002-6735-583X
|b 11
773 _ _ |a 10.1038/s44319-025-00594-3
|g Vol. 26, no. 22, p. 5533 - 5566
|0 PERI:(DE-600)2025376-X
|n 22
|p 5533 - 5566
|t EMBO reports
|v 26
|y 2025
|x 1469-221X
909 C O |o oai:inrepo02.dkfz.de:306541
|p VDB
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 9
|6 P:(DE-He78)4658b59d5b4e54b919fc63ab1213c78f
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-319H
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Addenda
|x 0
914 1 _ |y 2025
915 _ _ |a DEAL Wiley
|0 StatID:(DE-HGF)3001
|2 StatID
|d 2024-12-12
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2024-04-09T14:01:41Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2024-04-09T14:01:41Z
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Anonymous peer review, Double anonymous peer review
|d 2024-04-09T14:01:41Z
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
|d 2024-04-09T14:01:41Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-12
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-12
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-12
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b EMBO REP : 2022
|d 2024-12-12
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b EMBO REP : 2022
|d 2024-12-12
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2024-12-12
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2024-12-12
920 1 _ |0 I:(DE-He78)F140-20160331
|k F140
|l NWG Infection and Immune Sensing Dynamics
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)F140-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21