TY  - JOUR
AU  - Möller, Rika
AU  - Kamp, Benedikt
AU  - Leja, Paula
AU  - Thiel, Thomas A
AU  - Bechler, Eric
AU  - Wittsack, Hans-Jörg
AU  - Antoch, Gerald
AU  - Nagel, Armin
AU  - Wilms, Lena M
AU  - Frenken, Miriam
AU  - Müller-Lutz, Anja
TI  - Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon.
JO  - Magnetic resonance in medicine
VL  - 95
IS  - 4
SN  - 1522-2594
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2025-02658
SP  - 2180-2193
PY  - 2026
N1  - 2026 Apr;95(4):2180-2193
AB  - To evaluate partial volume correction (PVC) techniques for sodium MRI of the Achilles tendon in situ and in vivo.Five PVC methods were evaluated including a volume ratio of the proton and sodium segmentations (PSSR), a modified least trimmed square (3D-mLTS) linear regression, a geometric transfer matrix (GTM) approach, a single target correction (STC), and a novel estimated single target correction (eSTC). Their performance was tested using simulated data and 3 T MR data of two volunteers' Achilles tendons acquired at different resolutions: 1.5, 2.0, 3.0, and 4.5 mm3. Since there was no in vivo ground truth, the highest-resolution apparent tissue sodium contents (aTSC) were used.In the simulation, all PVC methods reduced the difference between the actual and calculated concentrations and were 11.69 ± 6.17 mM without PVC, 4.90 ± 5.40 mM with the PSSR, 4.86 ± 5.19 mM with the mLTS, 1.72 ± 4.13 mM with the GTM, 0.36 ± 1.77 mM with STC and 0.26 ± 1.63 mM with the eSTC. In vivo, the difference in aTSCs between the lower and the highest resolution decreased with all PVCs ranging from 3.6 to 38.8 mM without PVC, 2.8-20.4 mM with PSSR, 4.5-25.9 mM with mLTS, 0.9-7.8 mM with GTM, 0.1-23.8 mM with STC, and 0.7-7.7 mM with eSTC.PVC generally improved the accuracy of aTSC calculations. The newly introduced eSTC produced the most accurate results for the Achilles tendon.
KW  - 23Na‐MRI (Other)
KW  - Achilles tendon (Other)
KW  - partial volume correction (Other)
KW  - sodium MRI (Other)
KW  - sodium concentration (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41310405
DO  - DOI:10.1002/mrm.70208
UR  - https://inrepo02.dkfz.de/record/306665
ER  -