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| Home > Publications database > Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon. |
| Journal Article | DKFZ-2025-02658 |
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2025
Wiley-Liss
New York, NY [u.a.]
Abstract: To evaluate partial volume correction (PVC) techniques for sodium MRI of the Achilles tendon in situ and in vivo.Five PVC methods were evaluated including a volume ratio of the proton and sodium segmentations (PSSR), a modified least trimmed square (3D-mLTS) linear regression, a geometric transfer matrix (GTM) approach, a single target correction (STC), and a novel estimated single target correction (eSTC). Their performance was tested using simulated data and 3 T MR data of two volunteers' Achilles tendons acquired at different resolutions: 1.5, 2.0, 3.0, and 4.5 mm3. Since there was no in vivo ground truth, the highest-resolution apparent tissue sodium contents (aTSC) were used.In the simulation, all PVC methods reduced the difference between the actual and calculated concentrations and were 11.69 ± 6.17 mM without PVC, 4.90 ± 5.40 mM with the PSSR, 4.86 ± 5.19 mM with the mLTS, 1.72 ± 4.13 mM with the GTM, 0.36 ± 1.77 mM with STC and 0.26 ± 1.63 mM with the eSTC. In vivo, the difference in aTSCs between the lower and the highest resolution decreased with all PVCs ranging from 3.6 to 38.8 mM without PVC, 2.8-20.4 mM with PSSR, 4.5-25.9 mM with mLTS, 0.9-7.8 mM with GTM, 0.1-23.8 mM with STC, and 0.7-7.7 mM with eSTC.PVC generally improved the accuracy of aTSC calculations. The newly introduced eSTC produced the most accurate results for the Achilles tendon.
Keyword(s): 23Na‐MRI ; Achilles tendon ; partial volume correction ; sodium MRI ; sodium concentration
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