TY  - JOUR
AU  - Zhang, Kevin Sun
AU  - Glemser, Philip Alexander
AU  - Neelsen, Christian Jan Oliver
AU  - Wennmann, Markus
AU  - Rotkopf, Lukas Thomas
AU  - Netzer, Nils
AU  - Meinzer, Clara
AU  - Hielscher, Thomas
AU  - Weru, Vivienn
AU  - Görtz, Magdalena
AU  - Stenzinger, Albrecht
AU  - Hohenfellner, Markus
AU  - Schlemmer, Heinz-Peter
AU  - Bonekamp, David
TI  - Repeatability and reproducibility of maximum diameter measurements of prostate lesions on MRI with repositioning and variation of imaging sequences: A test-retest study.
JO  - Magnetic resonance imaging
VL  - 127
SN  - 0730-725X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-02664
SP  - 110578
PY  - 2026
N1  - #EA:E010#LA:E010# / Volume 127, April 2026, 110578
AB  - To assess variability of maximum diameter measurements of prostate lesions in MRI assessing patient repositioning, rater and sequence effects.Forty-two patients were included retrospectively, who received a clinical bi-/multiparametric prostate MRI examination and agreed to have the T2-weighted (T2WI) and diffusion weighted-imaging (DWI) sequences scanned twice. Maximum diameter measurements of prostate lesions mentioned in the clinical radiologist reports were performed by four readers in multiple reading sessions for determination of inter-sequence (between two DWI sequences), inter-scan (between clinical and additional scan), intra-rater and inter-rater variability. The primary calculated metrics were the repeatability and reproducibility coefficient (RC/RDC), including pooled RC/RDC.Variability measured by RCs/RDCs was lowest for measurements obtained within the same reading session, with inter-scan RCs up to 5.6 mm/6.5 mm for T2WI/DWI, pooled RCs of 4.8 mm/5.8 mm, respectively, and inter-sequence RDCs of 5.4 mm-5.9 mm, pooled RDC 5.8 mm. Measurements performed in separate reading sessions demonstrated significantly higher variability for both settings in the majority of cases (RCs: up to 10.9 mm/11.7 mm/10.2 mm for T2WI/DWI/inter-sequence, p ≤ 0.002), pooled RCs/RDCs 9.2 mm-9.9 mm. Measurements necessarily generated in different reading sessions, i.e., intra-rater or inter-rater, demonstrated high variability (RCs/RDCs up to 11.4 mm/11.5 mm for T2WI/DWI).Prostate lesion measurements demonstrate considerable variability. When measured in one reading session by one rater, lesion diameter differences below the pooled RCs of 4.8 mm, 95 
KW  - Dimensional measurement accuracy (Other)
KW  - Magnetic resonance imaging (Other)
KW  - Observer variation (Other)
KW  - Prostate (Other)
KW  - Reproducibility of results (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41317885
DO  - DOI:10.1016/j.mri.2025.110578
UR  - https://inrepo02.dkfz.de/record/306671
ER  -