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| Home > Publications database > Distribution and prognostic value of T-cells in primary colorectal cancer and adjacent non-tumor mucosa in stage IV versus stage I-III patients. |
| Home > Publications database > Distribution and prognostic value of T-cells in primary colorectal cancer and adjacent non-tumor mucosa in stage IV versus stage I-III patients. |
| Journal Article | DKFZ-2026-00009 |
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2026
Wiley-Liss
Bognor Regis
Abstract: Analyzing T-cell subsets in and between primary colorectal cancer (pCRC) and adjacent non-tumor mucosa (NM) may reveal distinct prognostic value in stage IV versus stages I-III patients. Specimens of pCRC and NM were collected retrospectively from stage IV patients (n = 55) with synchronous liver metastases (LM), and stages I-III patients (n = 44) who developed metachronous LM. CD3+, CD8+, CD45RO+, CD4+, and Foxp3+ T-cells were quantified in NM and the tumor center (TC) of pCRC using immunohistochemistry. T-cell densities in NM and TC and their ratios (TC/NM) were tested as prognostic variables for overall survival (OS), along with Foxp3+/CD8+, Foxp3+/CD4+ and CD4+/CD8+ ratios. In stages I-III, associations with the time to occurrence of LM were also evaluated. In both groups, NM exhibited greater densities of CD3+, CD8+, CD45RO+, and CD4+ cells compared to TC, whereas Foxp3+ cells were more abundant in the TC. In stage IV, high densities of Foxp3+ cells, high Foxp3+/CD4+ and Foxp3+/CD8+ ratios in the NM, and high CD4+ cell densities in the TC were associated with longer OS. Stages I-III patients with a high CD4+/CD8+ ratio in the NM had longer OS, whereas a high Foxp3+/CD8+ ratio in the TC was associated with a shorter time to LM. We revealed a significant difference in the T-cell landscape between pCRC and adjacent NM with Foxp3+ cells predominating in the TC and other subsets in the NM. Assessing T-cells and their ratios in both regions may improve prediction of survival in CRC patients and the time to LM in stages I-III.
Keyword(s): T‐cells ; adjacent non‐tumor mucosa ; liver metastases ; primary colorectal cancer ; survival
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