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000307508 1001_ $$00000-0003-4125-9476$$aBaudon, Angel$$b0
000307508 245__ $$aStress induces oxytocin-Gαi-dependent remodeling of astrocytes to shape neuronal response in the amygdala.
000307508 260__ $$a[London]$$bSpringer Nature$$c2026
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000307508 520__ $$aAnticipated reactions to stressful situations are vital for the survival and well-being of organisms, and abnormal reactions results in stress-related disorders. The neuropeptide oxytocin is a key modulator ensuring well-adapted stress responses. Oxytocin acts on both neurons and astrocytes, but the molecular and cellular mechanisms mediating stress response remain poorly understood. Here, we focus on the amygdala, a crucial hub that integrates and processes sensory information through oxytocin-dependent mechanisms. Using an acute stress paradigm in mice, genetic and pharmacological manipulations combined with proteomic, morphological, electrophysiological and behavioral approaches, we reveal that oxytocinergic modulation of the freezing response to stress is mediated by transient Gαi-dependent retraction of astrocytic processes, followed by enhanced neuronal sensitivity to extracellular potassium in the amygdala. Our findings elucidate a pivotal role for astrocytes morphology-dependent modulation of brain circuits that is required for proper anticipated behavioral response to stressful situations.
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000307508 7001_ $$aGrelot, Valentin$$b1
000307508 7001_ $$aWang, Kai-Yi$$b2
000307508 7001_ $$aAlthammer, Ferdinand$$b3
000307508 7001_ $$aDenis, Clémence$$b4
000307508 7001_ $$aRiché-Piotaix, Pierre$$b5
000307508 7001_ $$0P:(DE-He78)fa6b819153e363b6f7168fe84ee42cde$$aAli, Syed Azmal$$b6$$udkfz
000307508 7001_ $$aYan, Yudong$$b7
000307508 7001_ $$aCastillo Díaz, Fernando$$b8
000307508 7001_ $$aPiacentini, Francesca$$b9
000307508 7001_ $$aClauss Creusot, Etienne$$b10
000307508 7001_ $$aHovhannisyan, Volodya$$b11
000307508 7001_ $$00009-0003-1696-4402$$aSchubert, Tim$$b12
000307508 7001_ $$aKleinwaechter, Annabel C$$b13
000307508 7001_ $$aEisemann, Eva M$$b14
000307508 7001_ $$aMuhammad, Jabir Aliyu$$b15
000307508 7001_ $$aHelen, Jemima$$b16
000307508 7001_ $$aLakomy, Tom$$b17
000307508 7001_ $$00000-0003-1431-5591$$aKrabichler, Quirin$$b18
000307508 7001_ $$aBreton, Rachel$$b19
000307508 7001_ $$aAndry, Virginie$$b20
000307508 7001_ $$00000-0002-3312-5956$$aCarrillo-de Sauvage, Maria-Angeles$$b21
000307508 7001_ $$aDemais, Valérie$$b22
000307508 7001_ $$aCès, Aurélia$$b23
000307508 7001_ $$00009-0006-1696-3030$$aFranke, Felix$$b24
000307508 7001_ $$aSchommer, Franziska$$b25
000307508 7001_ $$aKremer, Mélanie$$b26
000307508 7001_ $$aDi Benedetto, Barbara$$b27
000307508 7001_ $$aGoumon, Yannick$$b28
000307508 7001_ $$00000-0002-2148-7490$$aSchaaf, Christian P$$b29
000307508 7001_ $$aGrinevich, Valery$$b30
000307508 7001_ $$00000-0002-5574-888X$$aRouach, Nathalie$$b31
000307508 7001_ $$00000-0002-7772-9604$$aDarbon, Pascal$$b32
000307508 7001_ $$aNeumann, Inga D$$b33
000307508 7001_ $$00000-0003-2531-5175$$aAdamantidis, Antoine$$b34
000307508 7001_ $$00000-0003-3387-2190$$aBusnelli, Marta$$b35
000307508 7001_ $$aBenhaim, Lucile$$b36
000307508 7001_ $$0P:(DE-He78)939d5891259c638c1ab053b1456a578c$$aKrijgsveld, Jeroen$$b37$$udkfz
000307508 7001_ $$00000-0001-7085-1431$$aPfrieger, Frank W$$b38
000307508 7001_ $$00000-0003-4837-3706$$aCharlet, Alexandre$$b39
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