Journal Article (Review Article)

DKFZ-2026-00068

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity.

Moreno-Sanchez, P. M. ; Rezaeipour, M. ; Inderberg, E. M. ; Platten, M.DKFZ* ; Golebiewska, A.

2026
Nature Research London

Abstract: Plasticity is a hallmark of aggressive tumors, including glioblastoma (GBM), enabling tumor cells and the tumor microenvironment (TME) to adapt to diverse niches and evade treatment. Here, we discuss how innate and adaptive immune players cooperate in time and space to create an immunosuppressive TME that supports GBM growth and confers resistance to conventional treatments and immunotherapies. We highlight how therapeutic interventions reshape the TME, underscoring the need for targeted approaches to overcome resistance. We introduce the concepts of local TME priming and TME rewiring as necessary foundations for achieving more effective and durable clinical responses in the future.

Note: 2026 Jan;7(1):29-42

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Contributing Institute(s):

1. KKE Neuroimmunologie und Hirntumorimmunologie (D170)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Nature ; Essential Science Indicators ; IF >= 20 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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