Journal Article

DKFZ-2026-00286

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png TISSUE-SPECIFIC SPATIAL REGULATION OF INNATE IMMUNE CHECKPOINTS IN CANCER.

Stojanovic, A. ; Giorgetta, S. ; Vonhören, D.DKFZ* ; Krieghoff-Henning, E.DKFZ* ; Platten, M.DKFZ* ; Loges, S.DKFZ* ; Tugues, S. ; Cerwenka, A.

2026
[Verlag nicht ermittelbar] Philadelphia, Pa.

Abstract: Natural killer (NK) and innate lymphoid cells (ILCs) regulate tissue homeostasis and immune responses, by acting as early sensors of cellular stress and tissue dysfunction. Their functions are tightly controlled by regulatory circuits, often referred to as checkpoints, and are profoundly shaped by local environments. In cancer, tissue perturbations cause immune cell recruitment, spatial re-distribution, and accordant functional adaptations. Here, we discuss how tissue-specific cues regulate NK/ILC functions in cancer, and how local regulatory circuits shape their cellular states and effector programs. We address how targeting innate checkpoints could aid existing, and inform novel strategies for treating solid malignancies.

Note: epub

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Contributing Institute(s):

1. KKE Neuroimmunologie und Hirntumorimmunologie (D170)
2. Personalisierte Medizinische Onkologie (A420)

Research Program(s):

1. 319H - Addenda (POF4-319H) (POF4-319H)

Appears in the scientific report 2026

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF >= 25 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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